Basic and Clinical Neuroscience Journal
مجله علوم اعصاب پایه و بالینی
BCN
Medical Sciences
http://bcn.iums.ac.ir
137
journal137
2008-126X
2228-7442
10.32598/bcn
en
jalali
1396
12
1
gregorian
2018
3
1
0
Accepted Articles
online
1
fulltext
en
Temporal Dynamics of the Neural Response to Drug Cues: An fMRI Study among Methamphetamine Users
Cognitive Neuroscience
Cognitive Neuroscience
Original
Original
<div style="text-align: justify;"><strong>Objective</strong><em>:</em> Cue-induced craving is central to addictive disorders. Most cue-reactivity fMRI studies are analysed statically and report averaged signals, disregarding the dynamic nature of craving and task fatigue.<br>
<strong>Methods</strong><em>:</em> Thirty-two early abstinent methamphetamine users underwent fMRI-scanning while viewing visual methamphetamine cues. A Craving>Neutral contrast was obtained in regions of interest. To explore changes over time, the pre-processed signal was divided into three intervals. Contrast estimates were calculated within each interval, and were compared using ANOVA followed by post hoc t-tests. The results were compared with those from a static analysis across all blocks.<br>
<strong>Results</strong><em>:</em> A priori expected activations in the prefrontal cortex, insula and striatum not detected by static analysis were discovered by the dynamic analysis. Post hoc tests revealed distinct temporal activation patterns in several regions. Most showed rapid activation (including both ventral/dorsal striata and most regions in the prefrontal, insular and cingulate cortices) whereas some had delayed activation (the right anterior insula, left middle frontal gyrus, and left dorsal anterior cingulate cortex).<br>
<strong>Conclusions</strong><em>:</em> This study provides preliminary insights into the temporal dynamicity of cue-reactivity, and the potential of a conventional blocked-design task to consider it using a simple dynamic analysis. We highlight regional activations that were only uncovered by a dynamic analysis, and discuss the interesting and theoretically expected early versus late regional activation patterns. Rapidly activated regions are mostly those involved in the earlier stages of cue-reactivity, while regions with later activation participate in cognitive functions relevant later, such as reappraisal, interoception and executive control.</div>
Cue reactivity, Addiction, Methamphetamine, fMRI, Craving
0
0
http://bcn.iums.ac.ir/browse.php?a_code=A-10-3126-1&slc_lang=en&sid=1
Mohamad B.
Soleymani
Tahersoleymani@yahoo.com
13700319475328460035482
13700319475328460035482
No
Sharif University of Technology, Tehran, Iran.
Arshiya
Sangchooli
a-sangchooli@student.tums.ac.ir
13700319475328460035483
13700319475328460035483
No
Iranian National Center for Addiction Studies (INCAS), Tehran University of Medical Sciences, Tehran, Iran.
Mitra
Ebrahimpoor
mitra.ebrahimpoor@gmail.com
13700319475328460035484
13700319475328460035484
No
Neuroimaging and Analysis Group, Imam Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran.
Mohamad A.
Najafi
maminnajafik@gmail.com
13700319475328460035485
13700319475328460035485
No
Sharif University of Technology, Tehran, Iran.
Bijan
Vosoughi Vahdat
vahdat@sharif.edu
13700319475328460035486
13700319475328460035486
No
Sharif University of Technology, Tehran, Iran.
Alireza
Shahbabaie
shahbabaie.ar@gmail.com
13700319475328460035487
13700319475328460035487
No
Iranian National Center for Addiction Studies (INCAS), Tehran University of Medical Sciences, Tehran, Iran.
Mohammad Ali
Oghabian
oghabian@gmail.com
13700319475328460035488
13700319475328460035488
No
Neuroimaging and Analysis Group, Imam Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran.
Hamed
Ekhtiari
H_ekhtiari@razi.tums.ac.ir
13700319475328460035489
13700319475328460035489
Yes
Iranian National Center for Addiction Studies (INCAS), Tehran University of Medical Sciences, Tehran, Iran.