Basic and Clinical Neuroscience Journal
مجله علوم اعصاب پایه و بالینی
BCN
Medical Sciences
http://bcn.iums.ac.ir
137
journal137
2008-126X
2228-7442
10.32598/bcn
en
jalali
1401
6
1
gregorian
2022
9
1
13
5
online
1
fulltext
en
Differential Aspects of Natural and Morphine Reward-related Behaviors in Conditioned Place Preference Paradigm
Behavioral Neuroscience
Behavioral Neuroscience
Original
Original
<strong>Introduction:</strong> Natural rewards are essential for survival. However, drug-seeking behaviors can be maladaptive and endanger survival. The present study was conducted to enhance our understanding of how animals respond to food and morphine as natural and drug rewards, respectively, in a conditioned place preference (CPP) paradigm.<br>
<strong>Methods:</strong> We designed a protocol to induce food CPP and compare it as a natural reward with morphine CPP in rats. The protocol for reward induction in both groups (foods and morphine) consisted of three phases: pre-test, conditioning, and post-test. In morphine groups, we injected morphine as a reward (5 mg/kg, SC). To induce natural reward, we used two different protocols. In the first one, the rats were deprived of food for 24 h. In the other method, the rats were restricted to food for 14 days. During the conditioning period, the animals received daily chow, biscuits, or popcorn as a reward inducer.<br>
<strong>Results:</strong> Results revealed that CPP was not induced in food-deprived rats. A combination of food restriction (as a facilitator) and a biscuit or popcorn-induced reward using CPP. In contrast, food deprivation did not facilitate food CPP in response to regular food. Interestingly the CPP score of the group which received biscuits during a 7-day conditioning period was more than that of the morphine group.<br>
<strong>Conclusion:</strong> In conclusion, food restriction could be a better protocol than food deprivation to facilitate food reward.
Natural reward, Morphine reward, Food deprivation, Food restriction, Conditioned place preference, Rat
731
744
http://bcn.iums.ac.ir/browse.php?a_code=A-10-3071-1&slc_lang=en&sid=1
Shole
Jamali
13700319475328460042811
13700319475328460042811
No
Neuroscience Research Center, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Mahdi
Aliyari Shoorehdeli
13700319475328460042812
13700319475328460042812
No
Department of Mechatronics, School of Electrical Engineering, K. N. Toosi University of Technology, Tehran, Iran.
Mohammad Reza
Daliri
13700319475328460042813
13700319475328460042813
No
School of Cognitive Sciences, Institute for Research in Fundamental Sciences, Tehran, Iran.
Abbas
Haghparast
haghparast@yahoo.com
13700319475328460042814
13700319475328460042814
Yes
Neuroscience Research Center, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.