Basic and Clinical Neuroscience Journal

en Protective Effects of N-Acetyl-L-cystein on 3,4-Methylene Dioxymethamphetamie-Induced Neurotoxicity in Cerebellum of Male Rats Clinical Neuroscience Clinical Neuroscience Original Original Introduction: 3-4, methylenedioxymethamphetamine (MDMA) causes apoptosis in nervous system and several studies suggest that oxidative stress contributes to MDMA-induced neurotoxicity. The aim of this study is to examine the effects of N-acetyl-L-Cystein (NAC) as an antioxidant on MDMA-induced apoptosis. Methods: 21 Sprague dawley male rats (200-250mg) were treated with MDMA (2×0,5mg/kg) or MDMA plus NAC (100mg/kg IP for 7 day). After last administration of MDMA, rats were killed, cerebellum was removed and Bax and Bcl-2 expression was assessed by western blotting method. Results: The results of this study showed that MDMA causes up-regulation of Bax and down-regulation of Bcl-2 and NAC administration attenuated MDMA-induced apoptosis. Discussion: The present study suggests that NAC treatment may improve MDMA-induced neurotoxicity. Apoptosis,N-Methyl-3,4-Methylenedioxyamphetamine,Acetylcysteine 44 47 http://bcn.iums.ac.ir/browse.php?a_code=A-10-1-90&slc_lang=en&sid=1 Sara Soleimani Asl 1370031947532846001434 1370031947532846001434 Yes Peiman Falahati 1370031947532846001435 1370031947532846001435 No Nima shekar riz 1370031947532846001436 1370031947532846001436 No Nima Molavi 1370031947532846001437 1370031947532846001437 No Farzaneh Esmaeili 1370031947532846001438 1370031947532846001438 No Zahra Azimi 1370031947532846001439 1370031947532846001439 No Freidoon Sajadi 1370031947532846001440 1370031947532846001440 No Parisa Hayat 1370031947532846001441 1370031947532846001441 No Alireza Samzadeh-Kermani 1370031947532846001442 1370031947532846001442 No Mehdi Mehdizadeh 1370031947532846001443 1370031947532846001443 No