Basic and Clinical Neuroscience Journal
مجله علوم اعصاب پایه و بالینی
BCN
Medical Sciences
http://bcn.iums.ac.ir
137
journal137
2008-126X
2228-7442
10.32598/bcn
en
jalali
1401
12
1
gregorian
2023
3
1
14
2
online
1
fulltext
en
Shielding Effect of Ryanodine Receptor Modulator in Rat Model of Autism
Behavioral Neuroscience
Behavioral Neuroscience
Original
Original
<div style="text-align: justify;"><span style="font-size:14px;"><span style="font-family:Tahoma;"><span style="line-height:2;"><strong>Introduction</strong>: A neurodevelopmental disorder, autism is typically identified with three primary behavioral consequences, such as social impairment, communication problems, and limited or stereotypical behavior. Because of its co-morbidity and lack of therapeutic options, autism is a global economic burden. A short chain of fatty acid, propionic acid is formed biologically by the gut microbiome. Propionic acid levels that are too high can cause leaky intestines, which can lead to autism-like symptoms.<br>
<strong>Methods</strong>: To induce autism, male Albino Wistar rats were given propionic acid (250 mg/kg/po on the 21st, 22nd, and 23rd postnatal days). Rats also received a ryanodine receptor antagonist (Ruthenium red: 3 mg/kg/po; postnatal 21st to 50th day) to see what influence it had on propionic acid-induced autism. Anxiety, social behavior, and repeated behaviors were all assessed, as well as oxidative stress, inflammatory indicators, neuro signaling proteins, and blood-brain barrier permeability.<br>
<strong>Results</strong>: Ruthenium red was found to counter the propionic acid-induced increases in anxiety, repetitive behavior prefrontal cortex levels of IL-6, TNF-α, TBARS, Evans blue leakage, and water content along with decreases in social behavior, IL-10, and GSH followed by hippocampus CREB and BDNF levels. <br>
<strong>Conclusion</strong>: Ryanodine receptor antagonists presented a neuroprotective effect in propionic acid-induced conditions like autism by modulatory effects on social and repetitive behavior, oxidative stress, neuroinflammation, and neuroprotein changes. Ryanodine receptors can be further explored in depth to manage autism as a condition. </span></span></span></div>
BDNF, Ryanodine, Interleukins-6, Mitochondria, Blood brain barrier, ASST
247
262
http://bcn.iums.ac.ir/browse.php?a_code=A-10-2966-1&slc_lang=en&sid=1
Hariom
Kumar
sharmaslab7@gmail.com
13700319475328460044866
13700319475328460044866
No
Department of Pharmacology, Amity Institute of Pharmacy, Amity University, Nodia, India.
G.T.
Kulkarni
gtkresearch20@gmail.com
13700319475328460044867
13700319475328460044867
No
Department of Pharmacology, Amity Institute of Pharmacy, Amity University, Nodia, India.
Vishal
Diwan
vdiwan.aus@protonmail.ch
13700319475328460044868
13700319475328460044868
No
UQ Diamantina Institute, Translational Research Institute, The University of Queensland, Australia.
Bhupesh
Sharma
bhupeshsharmaresearch@gmail.com
13700319475328460044869
13700319475328460044869
Yes
Department of Pharmacology, Amity Institute of Pharmacy, Amity University, Nodia, India.