Basic and Clinical Neuroscience Journal
مجله علوم اعصاب پایه و بالینی
BCN
Medical Sciences
http://bcn.iums.ac.ir
137
journal137
2008-126X
2228-7442
10.32598/bcn
en
jalali
1400
2
1
gregorian
2021
5
1
12
3
online
1
fulltext
en
Glycine/NMDA Receptor Pathway Mediates the Rapid-onset Antidepressant Effect of Alkaloids From Trichilia Monadelpha
Behavioral Neuroscience
Behavioral Neuroscience
Original
Original
<strong>Introduction</strong>: Major depressive disorder is often associated with suicidal tendencies, and this condition accentuates the need for rapid-acting antidepressants. We previously reported that Alkaloids (ALK) from Trichilia monadelpha possess antidepressant action in acute animal models of depression and that this effect is mediated through the monoamine and L-arginine-NO-cGMP pathways. This study investigated the possible rapid-onset antidepressant effect of ALK from T. monadelpha and its connection with the glycine/NMDA receptor pathway.<br>
<strong>Methods</strong>: The onset of ALK action from T. monadelpha was evaluated using the Open Space Swim Test (OSST), a chronic model of depression. The modified forced swimming and tail suspension tests were used to assess the effect of the ALK on the glycine/NMDA receptor pathway. The Instutute of Cancer Research (ICR) mice were treated with either ALK (30–300 mg/kg, orally [PO]), imipramine (3–30 mg/kg, PO), fluoxetine (3–30 mg/kg, PO), or saline. To identify the role of glycine/NMDA receptor pathway in the effect of ALK, we pretreated mice with a partial agonist of the glycine/NMDA receptor, D-cycloserine (2.5 mg/kg, intraperitoneally [IP]), and an agonist of glycine/NMDA receptor, D-serine (600 mg/kg, IP), before ALK administration.<br>
<strong>Results</strong>: ALK reversed immobility in mice after the second day of drug treatment in the OSST. In contrast, there was a delay in the effects induced by fluoxetine and imipramine. ALK also increased mean swimming and climbing scores in mice. ALK was more efficacious than imipramine and fluoxetine in reducing immobility and increasing distance traveled. It is noteworthy that ALK was less potent than fluoxetine and imipramine. D-cycloserine potentiated mobility observed in the ALK- and fluoxetine-treated mice. In contrast, D-serine decreased mobility in the ALK-treated mice.<br>
<strong>Conclusion</strong>: The study results suggest that ALK from T. monadelpha exhibits rapid antidepressant action in mice, and the glycine/NMDA receptor pathway possibly mediates the observed effect.
Glycine/NMDA receptor, Open space swim test, Rapid-acting antidepressant, Trichilia, Alkaloids
395
408
http://bcn.iums.ac.ir/browse.php?a_code=A-10-2838-1&slc_lang=en&sid=1
Kennedy Kwami
Edem Kukuia
edemkennedy@yahoo.com
13700319475328460035989
13700319475328460035989
Yes
Department of Medical Pharmacology, University of Ghana Medical School, College of Health Sciences, University of Ghana, Korle Bu-Accra, Ghana.
Jeffrey
Amoako Mensah
jeffreyamoako.mensah@utah.edu
13700319475328460035990
13700319475328460035990
No
Department of Pharmacology and Toxicology, College of Pharmacy, University of Utah, Salt Lake City, UT, U.S. A.
Patrick
Amoateng
pamoateng@ug.edu.gh
13700319475328460035991
13700319475328460035991
No
Department of Pharmacology and Toxicology, School of Pharmacy, College of Health Sciences, University of Ghana, Legon-Accra, Ghana.
Dorcas
Osei-Safo
doseisafo@ug.edu.gh
13700319475328460035992
13700319475328460035992
No
Department of Chemistry, School of Physical and Mathematical Sciences, College of Basic and Applied Sciences, University of Ghana, Legon-Accra, Ghana.
Awo
Efua Koomson
diamondefua@ymail.com
13700319475328460035993
13700319475328460035993
No
Department of Pharmacology and Toxicology, School of Pharmacy, College of Health Sciences, University of Ghana, Legon-Accra, Ghana.
Joseph
Torbi
jtorbi@st.ug.edu.gh
13700319475328460035994
13700319475328460035994
No
Department of Pharmacology and Toxicology, School of Pharmacy, College of Health Sciences, University of Ghana, Legon-Accra, Ghana.
Donatus
Wewura Adongo
donatusadongo@yahoo.com
13700319475328460035995
13700319475328460035995
No
Department of Pharmacology and Toxicology, School of Pharmacy, University of Health and Allied Sciences, Ho, Ghana.
Elvis
Ofori Ameyaw
13700319475328460035996
13700319475328460035996
No
Department of Pharmacology, School of Pharmacy and Pharmaceutical Sciences, University of Cape Coast, Cape Coast, Ghana.
Inemesit
Okon Ben
13700319475328460035997
13700319475328460035997
No
Department of Pharmacology and Toxicology, School of Pharmacy, University of Health and Allied Sciences, Ho, Ghana.
Seth
Kwabena Amponsah
13700319475328460035998
13700319475328460035998
No
Department of Medical Pharmacology, University of Ghana Medical School, College of Health Sciences, University of Ghana, Korle Bu-Accra, Ghana.
Kwasi
Agyei Bugyei
13700319475328460035999
13700319475328460035999
No
Department of Medical Pharmacology, University of Ghana Medical School, College of Health Sciences, University of Ghana, Korle Bu-Accra, Ghana.
Isaac Julius
Asiedu-Gyekye
13700319475328460036000
13700319475328460036000
No
Department of Pharmacology and Toxicology, School of Pharmacy, College of Health Sciences, University of Ghana, Legon-Accra, Ghana.