en Clinical Neuroscience Clinical Neuroscience Original Original <p align="left" ><font color="#221e1f" size="2"><font color="#221e1f" size="2"><p align="left" ><p><strong><font color="#221e1f" size="2"><font color="#221e1f" size="2">Introduction: </font></font><font color="#221e1f" face="Times New Roman,Times New Roman" size="2"><font color="#221e1f" face="Times New Roman,Times New Roman" size="2"><font color="#221e1f" face="Times New Roman,Times New Roman" size="2">Several supra spinal areas such as rostral ventrolateral medulla (RVLM) area are involved in basic cardiovascular regulation. The Kolliker— Fuse nucleus (KF) is located in pons and is heavily connected with RVLM. The cardiovascular effect of KF nucleus has been shown and it is suggested that KF is involved in sympathetic vasomotor tone and basic cardiovascular regulation. Therefore, in the present study, the effects of KF on basic cardiovascular values were evaluated. </font></font></font></strong><font color="#221e1f" size="2"><font color="#221e1f" size="2"><p align="justify"><strong>Methods: </strong></p></font></font><font color="#221e1f" face="Times New Roman,Times New Roman" size="2"><font color="#221e1f" face="Times New Roman,Times New Roman" size="2"><font color="#221e1f" face="Times New Roman,Times New Roman" size="2">After induction of anesthesia, a polyethylene catheter (PE-50) filled </font></font></font><font color="#221e1f" face="Times New Roman,Times New Roman" size="2"><font color="#221e1f" face="Times New Roman,Times New Roman" size="2"><font color="#221e1f" face="Times New Roman,Times New Roman" size="2">with heparinized saline was inserted into the femoral artery of rats. Animals were then placed in a stereotaxic apparatus and KF nucleus was inactivated by microinjection of cobalt chloride (CoCl2). Blood pressure and heart rate (HR) were continuously recorded pre and post inactivation. </font></font></font><font color="#221e1f" size="2"><font color="#221e1f" size="2"><p align="justify"><strong>Results: </strong></p></font></font><font color="#221e1f" face="Times New Roman,Times New Roman" size="2"><font color="#221e1f" face="Times New Roman,Times New Roman" size="2"><font color="#221e1f" face="Times New Roman,Times New Roman" size="2">Our result showed that inactivation of KF slightly changed mean arterial blood pressure (MAP) (92.3 ± 2.45 mmHg vs. 90.86 ± 1.7 mmHg) and HR (343.8 ± 4.6 beats/min vs. 350.7 ± 8.32 beats /min). However, these effects were not </font></font></font><font color="#221e1f" face="Times New Roman,Times New Roman" size="2"><font color="#221e1f" face="Times New Roman,Times New Roman" size="2"><font color="#221e1f" face="Times New Roman,Times New Roman" size="2">significant in comparison to the control group. </font></font></font><font color="#221e1f" size="2"><font color="#221e1f" size="2"><p><strong>Discussion: </strong></p></font></font><font color="#221e1f" face="Times New Roman,Times New Roman" size="2"><font color="#221e1f" face="Times New Roman,Times New Roman" size="2"><font color="#221e1f" face="Times New Roman,Times New Roman" size="2">We concluded that synapses in the KF nucleus have no effect on regulation of basal blood pressure and heart rate, because CoCl2 is a synaptic blocker. </font></font></font></p></font></font> Kolliker-Fuse nucleus,CoCl2,Blood Pressure,Heart Rate,Reversible Inactivation 4 8 http://bcn.iums.ac.ir/browse.php?a_code=A-10-1-81&slc_lang=en&sid=1 Mohammad Naser Shafei 1370031947532846001465 1370031947532846001465 Yes Hojatallah Alaei 1370031947532846001466 1370031947532846001466 No Esmaeil Farrokhi 1370031947532846001467 1370031947532846001467 No