Basic and Clinical Neuroscience Journal
مجله علوم اعصاب پایه و بالینی
BCN
Medical Sciences
http://bcn.iums.ac.ir
137
journal137
2008-126X
2228-7442
10.32598/bcn
en
jalali
1396
12
1
gregorian
2018
3
1
0
Accepted Articles
online
1
fulltext
other
The Association Between Dietary Antioxidants, Superoxide Dismutase Activity, and Serum Levels of Inflammatory Factors in Children With ADHD
<strong>Introduction: </strong>Recent studies have identified ADHD as an inflammatory condition with immunological and oxidative responses. Therefore, it is necessary to examine these factors in the patients. This study aimed to investigate the relationship between the dietary intakes of antioxidants, SOD activity and the serum levels of inflammatory factors in children with ADHD.<br>
<strong>Materials and methods</strong>: This study was a retrospective case-control study with 64 ADHD children aged 6 to 13 years. The demographic questionnaire, FFQ, and Baecke physical activity questionnaire were used. SOD activity and the serum level of inflammatory factors (homocysteine, IL-6, and CRP) were measured in all patients. Based on the values obtained from CRP, 32 patients were included in the case group (CRP≥1 mg/L) and 32 patients in the control group (0≤CRP<1 mg/L).<br>
<strong>Results</strong>: There was no significant difference between the two groups as regards age, sex, weight, height, body mass index (BMI). In the case group, the mean SOD activity score (P=0.034), the physical activity score (P=0.04) and the zinc intake (P=0.02) and homocysteine levels were higher than they were in the control group (P=0.001). Among the variables in the presence of each other, the best predictors were homocysteine (OR: 1.34, 95% CI: 1.082-1.670, P=0.029) and physical activity (OR: 0.85, 95% CI: 0.761-0.952, P=0.022) respectively, and in the presence of these two variables, other variables were not significant predictors.<br>
<strong>Conclusion:</strong> The present study showed that the level of inflammatory factors in the case group was significantly higher than the control group. Homocysteine and physical activity can predict the inflammatory status induced by CRP. Decreasing the antioxidant activity of SOD with increasing CRP levels, indicates oxidative stress associated with inflammation in these patients.
Antioxidants, Inflammation, C-Reactive protein, ADHD, Child
0
0
http://bcn.iums.ac.ir/browse.php?a_code=A-10-1489-2&slc_lang=other&sid=1
Iman
Namjoo
inamjoo91@gmail.com
13700319475328460034428
13700319475328460034428
No
Department of Community Nutrition, School of Nutrition and Food Sciences, Isfahan University of Medical Sciences, Isfahan, Iran.
Amirmansour
Alavi Naeini
am.alavi@nutr.mui.ac.ir
13700319475328460034429
13700319475328460034429
Yes
Department of Community Nutrition, School of Nutrition and Food Sciences, Isfahan University of Medical Sciences, Isfahan, Iran.
Mostafa
Najafi
najafimostafa@med.mui.ac.ir
13700319475328460034430
13700319475328460034430
No
Department of Psychiatry and Behavioral Sciences Research Center, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
Mohammad Reza
Aghaye Ghazvini
mr-ghazvini@farabi.tums.ac.ir
13700319475328460034431
13700319475328460034431
No
Isfahan Center of Health Research, National Institute of Health Research, Isfahan, Iran.
Akbar
Hasanzadeh
hassanzadeh@hlth.mui.ac.ir
13700319475328460034432
13700319475328460034432
No
Department of Biostatistics and Epidemiology, School of Health, Isfahan University of Medical Sciences, Isfahan, Iran.