en Clinical Neuroscience Clinical Neuroscience Original Original <div style="text-align: justify;"><span style="font-size:14px;"><span style="font-family:Tahoma;"><span style="line-height:2;"><span style="color:black"><b><span lang="FR">Objective:</span></b> Behavioral disorder is known as one of the most common side effects of levetiracetam (LEV). Previous studies in children and adolescents have noted the potential positive effects of pyridoxine in preventing these disorders. Pyridoxine (Vitamin B₆) is a water-soluble vitamin playing a pivotal role as a co-factor in regulating more than 100 enzymatic reactions such as GABA and serotonin synthesis and catabolism. This study aims at investigating the effects of pyridoxine on behavioral disorders, including depression, anxiety, and stress caused by levetiracetam. <span style="font-family:"Times New Roman","serif""></span></span><br> <span style="color:black"><b>Method</b>: A total of 38 patients who were prescribed levetiracetam by a neurologist were enrolled in the study following taking informed consent. They were randomly divided into two groups. A group of 19 people received pyridoxine 40 mg twice daily in the first two weeks and 40 mg 3 times per day for the next two weeks known as the intervention group. The remaining patients were taking only levetiracetam known as the control group. DASS 21 questionnaire was used to measure levetiracetam induced depression, anxiety, and stress at weeks 0 and 4.<span style="font-family:"Times New Roman","serif""></span></span><br> <span style="color:black"><b>Results</b>:<span style="background:white">&nbsp;In this study, 19 patients received LEV in different doses, and 19 received LEV plus pyridoxine 40 mg twice daily for 2 weeks following a 40 mg three times daily for two more weeks. After 4 weeks of treatment with both LEV and LEV plus pyridoxine, the results revealed that two treatments equally induced the LEV induced symptoms. After 4 weeks of treatment, the r</span>esults of this study did not show any significant differences between the intervention and control group.<span style="font-family:"Times New Roman","serif""></span></span><br> <span style="color:black"><b><span lang="IT">Conclusion</span></b>: This study suggests that pyridoxine may not be effective in preventing depression, anxiety, and stress-induced by levetiracetam in adult patients who are suffering from seizure disorders and are on levetiracetam.</span></span></span></span><span style="font-size:11pt"><span style="text-justify:inter-ideograph"><span helvetica="" neue="" style="font-family:"><span style="color:black"><span style="font-size:14.0pt"><span style="font-family:"Times New Roman","serif""></span></span></span></span></span></span></div> Pyridoxine, Vitamin B6, Levetiracetam, Depression, Anxiety, Stress 0 0 http://bcn.iums.ac.ir/browse.php?a_code=A-10-2503-1&slc_lang=en&sid=1 Fatemeh Zarei Hajiabadi atemeh.93.zarei@gmail.com 13700319475328460059076 13700319475328460059076 No Clinical Pharmacist, School of Pharmacy, Tehran University of Medical Sciences (TUMS), Tehran, Iran. Vajiheh Aghamollaii vajiheh102@gmail.com 13700319475328460059077 13700319475328460059077 Yes Neuropsychiatry Department, Roozbeh Hospital, Tehran University of Medical sSciences (TUMS), Tehran, Iran. Padideh Ghaeli mmppg@yahoo.com 13700319475328460059078 13700319475328460059078 No Roozbeh Hospital and School of Pharmacy, Tehran University of Medical Sciences (TUMS), Tehran, Iran. Abolfazl Mohammadi pghaeli63@gmail.com 13700319475328460059079 13700319475328460059079 No Department of Psychiatry, Tehran University of Medical Sciences (TUMS), Tehran, Iran. Samira Chaibakhsh smr.chaibakhsh@gmail.com 13700319475328460059080 13700319475328460059080 No Research Center for Rational Use of Drugs, Tehran University of Medical Sciences (TUMS), Tehran, Iran. Sana Khajepour sanakhajehpour@gmail.com 13700319475328460059081 13700319475328460059081 No Faculty of Pharmacy, Department of Biomedical and Pharmaceutical Sciences, Idaho State University, Idaho, USA.