en Cognitive Neuroscience Cognitive Neuroscience Original Original <strong>Introduction:</strong> Lack of high-quality sleep causes severe side effects like anxiety and changes in plasma concentration of oxalate. The current study investigated the impact of local extremely low-frequency magnetic fields (ELF-MFs) on inducing sleep (sleepiness) and anxiety in male rats.<br> <strong>Methods:</strong> In this experimental study, 40 male rats were divided into four groups (n=10 for each group). The ELF-MF exposure (0, 10, and 18 Hz) was applied with an intensity of 200&micro;T for three days (10 min/d). The sham-treated animal did not receive ELF-MF. Serum levels of oxalic acid (OA) and sleepiness were measured before and after the last exposure to ELF-MF or sham. Anxiety, sleepiness, and OA were measured using the elevated plus maze, open-field test (OFT), and ELISA test.<br> <strong>Results: </strong>A comparison of oxalate levels before and after exposure to ELF-MF revealed that ELF-MF (10 Hz) decreased the serum level of oxalate (P<0.05). Comparing open/closed arm entry (in an elevated plus maze) between before and after exposure to ELF-MF revealed significant differences. Also, frequency, velocity, and distance moved were decreased in the open-field test.<br> <strong>Conclusion:</strong> Results of the present study demonstrated that ELF-MF with short-time exposure may modulate the metabolism of OA and may modulate anxiety-like behavior or kind of induction of sleepiness in male rats. Magnetic field, Extremely low-frequency magnetic fields (ELF-MFs), Oxalic acid, Anxiety, Sleepiness 519 530 http://bcn.iums.ac.ir/browse.php?a_code=A-10-2610-1&slc_lang=en&sid=1 Elnaz Azizi 13700319475328460041926 13700319475328460041926 No Non-Communicable Diseases Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, Iran. Fatemeh Ayoobi 13700319475328460041927 13700319475328460041927 No Non-Communicable Diseases Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, Iran. Ali Shamsizadeh 13700319475328460041928 13700319475328460041928 No Physiology-Pharmacology Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, Iran. Amir Moghadam-Ahmadi 13700319475328460041929 13700319475328460041929 No Non-Communicable Diseases Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, Iran. Seyed Ali Shafiei sashafiei@muq.ac.ir 13700319475328460041930 13700319475328460041930 Yes Neuroscience Research Center, Qom University of Medical Sciences, Qom, Iran. Alireza Khoshdel 13700319475328460041931 13700319475328460041931 No Department of Biochemistry, School of Medicine, Semnan University of Medical Sciences, Semnan, Iran. Mohammad Reza Mirzaei 13700319475328460041932 13700319475328460041932 No Molecular Medicine Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.