en Cognitive Neuroscience Cognitive Neuroscience Original Original <div style="text-align: justify;"><span style="font-size:14px;"><span style="font-family:Tahoma;"><span style="line-height:2;"><strong>Introduction</strong>: The differences among dorsal and ventral hippocampal neural circuits affect synaptic plasticity. In this study, we aim to compare the occurrence of short-term plasticity in the field excitatory postsynaptic potential (fEPSP) in dorsal and ventral hippocampal CA1 areas following kindled seizures.<br> <strong>Methods</strong>: Animals (male C57 B6/J mice, 12 weeks of age) were kindled by intraperitoneal injections of pentylenetetrazole (PTZ), and fEPSPs were recorded from dorsal and ventral hippocampal slices. Short-term plasticity was evaluated by measuring fEPSP-slope and fEPSP-area following paired-pulse stimulation delivered at three inter-pulse intervals (20, 80, and 160 ms).<br> <strong>Results</strong>: In control slices, the fEPSP-slope was greater in the ventral hippocampus compared to the dorsal hippocampus, but there was no difference in the fEPSP-area between the two regions. In hippocampal slices, the fEPSP-slope was similar in the dorsal and ventral regions, but the fEPSP-area was greater in the ventral region compared to the dorsal region. In addition, the fEPSP-area was greater in the kindled group than in the control group only in the ventral hippocampus. PTZ-induced kindled slices showed impaired short-term facilitation, and the paired-pulse index decreased only in the dorsal hippocampus. Kindling had no significant effect on the paired-pulse ratio in the ventral hippocampus.<br> <strong>Conclusion</strong>: The seizure occurrence affects the neural activity of the hippocampus in a region-dependent manner. Although kindling increases the fEPSP area in the ventral hippocampus of mice, kindling-induced changes in short-term synaptic plasticity are significant only in the dorsal hippocampus. The difference in the responses of dorsal and ventral poles should be considered in future studies.</span></span></span></div> Seizure, Hippocampus, Paired-pulse index, Synaptic plasticity, Kindling 595 606 http://bcn.iums.ac.ir/browse.php?a_code=A-10-1854-1&slc_lang=en&sid=1 Nahid Roohi nahid.roohi66@gmail.com 13700319475328460050661 13700319475328460050661 No Department of Physiology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran. Mahboubeh Ahmadi mbh.ahmadi@gmail.com 13700319475328460050662 0009-0000-0719-3632 No Department of Physiology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran. Yaghoub Fathollahi fatolahi@modares.ac.ir 13700319475328460050663 13700319475328460050663 No Department of Physiology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran. Amir Shojaei am.shojaei@modares.ac.ir 13700319475328460050664 13700319475328460050664 No Department of Physiology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran. Javad Mirnajafi-Zadeh mirnajaf@modares.ac.ir 13700319475328460050665 13700319475328460050665 Yes Department of Physiology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran.