en Clinical Neuroscience Clinical Neuroscience Review Review Awareness of the current outbreak of Coronavirus Disease - 2019 (COVID-19) affecting the nervous system and identifying its possible ways to enter the Central Nervous System (CNS) are critical for the prevention and treatment of the disease. Hence, the CNS implications of the COVID-19 since the spread of the virus were reviewed in this study. COVID-19, Hypoxia, Neural pathway, ACE 217 224 http://bcn.iums.ac.ir/browse.php?a_code=A-10-2360-1&slc_lang=en&sid=1 Nooshin Ahmadirad ahmadiyerad@gmail.com 13700319475328460026438 13700319475328460026438 Yes Cellular and Molecular Research Center, Iran University of Medical Sciences, Tehran, Iran. Zahra Ghasemi ghasemi.z1985@gmail.com 13700319475328460026439 13700319475328460026439 No Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Canada.