en Behavioral Neuroscience Behavioral Neuroscience Commentary Commentary <strong>Introduction: </strong>To assess the opinion of patients with Multiple Sclerosis (MS) on the outcomes of COVID-19 (coronavirus disease 2019) and its effects on MS symptoms if they catch coronavirus. A cross-sectional study was performed.&nbsp;<br> <strong>Methods: </strong>Considering the study objectives, a questionnaire was designed and prepared as a Google Form for MS patients for one week.&nbsp;<br> <strong>Results:</strong> A total of 148 MS patients with an average age of 35.73 years completed the questionnaire. The most important concern of the participants was &ldquo;a high prevalence of COVID-19&rdquo; following by the &ldquo;MS symptoms worsening&rdquo;. Many participants (35%) believed that, if they catch COVID-19 they will be cured. However, the treatment will take more time for them in comparison with the general population. About 39.8% of the patients stated that COVID-19 infection does not affect the MS symptom, but others noted that, it can cause relapse (30.8%) or worsen MS symptoms (29.3%).<br> <strong>Conclusion:</strong> This study revealed that MS patients are more anxious about the effects of COVID-19 on their underlying disease rather than the infection itself.&nbsp; Multiple Sclerosis, Coronavirus disease 2019 (COVID-19), Outcome, Concerns 201 206 http://bcn.iums.ac.ir/browse.php?a_code=A-10-2520-1&slc_lang=en&sid=1 Nasim Rezaeimanesh 13700319475328460025985 13700319475328460025985 No Multiple Sclerosis Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran. Mohammad Ali Sahraian 13700319475328460025986 13700319475328460025986 No Multiple Sclerosis Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran. Abdorreza Naser Moghadasi abdorrezamoghadasi@gmail.com 13700319475328460025987 13700319475328460025987 Yes Multiple Sclerosis Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran.