Basic and Clinical Neuroscience Journal
مجله علوم اعصاب پایه و بالینی
BCN
Medical Sciences
http://bcn.iums.ac.ir
137
journal137
2008-126X
2228-7442
10.32598/bcn
en
jalali
1399
10
1
gregorian
2021
1
1
12
1
online
1
fulltext
en
Serum Eicosapentaenoic and Arachidonic Acids Concentration and Cognitive Function in Patients With Coronary Artery Disease
Clinical Neuroscience
Clinical Neuroscience
Original
Original
<strong>Introduction</strong>: Recent studies have shown that Polyunsaturated Fatty Acids (PUFAs), including Eicosapentaenoic Acid (EPA), and Arachidonic Acid (AA), are associated with cognitive functions in patients with Coronary Artery Disease (CAD). Nevertheless, controversial results have been reported, too. The current study aimed to clarify the association of serum EPA and AA levels with cognitive decline in an Iranian sample with CAD.<br>
<strong>Methods</strong>: We evaluated cognitive function with the Mini-Mental State Examination (MMSE) and Montreal Cognitive Assessment (MoCA), in relation to serum levels of EPA and AA, in 179 CAD patients. The associations between the MMSE and MoCA scores and the other demographic parameters were evaluated.<br>
<strong>Results</strong>: Patients with CAD generally had mild cognitive impairment. But we could not find any significant correlation between PUFAs and cognitive function. However, BMI was associated with EPA/MoCA; age was associated with MMSE/MoCA and BMI. Finally, the correlation between sex and MMSE/MoCA was significant. <br>
<strong>Conclusion</strong>: Subjects generally had mild cognitive impairment, but we could not find any significant correlation between serum EPA and AA levels with cognitive function.
Eicosapentaenoic acid, Arachidonic acid, Cognitive function, Mini Mental State Examination, Montreal cognitive assessment, Coronary artery disease
63
68
http://bcn.iums.ac.ir/browse.php?a_code=A-10-606-3&slc_lang=en&sid=1
Sadegh
Yoosefee
syoosefee@muq.ac.ir
13700319475328460031829
13700319475328460031829
No
Neurosciences Research Center, Qom University of Medical Sciences, Qom, Iran.
Maryam
Rahimi
m.rahimi0370@yahoo.com
13700319475328460031830
13700319475328460031830
No
Neurosciences Research Center, Qom University of Medical Sciences, Qom, Iran.
Fatemeh Sadat
Razavinia
fatemerazavi66@yahoo.com
13700319475328460031831
13700319475328460031831
No
Student Research Committee, Qom University of Medical Sciences, Qom, Iran.
Mostafa
Vahedian
vahedian58@gmail.com
13700319475328460031832
13700319475328460031832
No
Research Center for Environmental Pollutants, Qom University of Medical Sciences, Qom, Iran.
Ahmad Reza
Bagheri
Department of Cardiology, Faculty of Medicine, Qom University of Medical Sciences, Qom, Iran.
13700319475328460031833
13700319475328460031833
Yes
Department of Cardiology, Faculty of Medicine, Qom University of Medical Sciences, Qom, Iran.