en Clinical Neuroscience Clinical Neuroscience Review Review <div style="text-align: justify;"><strong>Introduction</strong>: Stroke is known as a common cause of disability all over the world. Stroke prognosis estimation has always been a topic of interest. In this study, it was tried to investigate the prognostic value of laboratory findings of complete blood count in a systematic review.<br> <strong>Methods</strong>: In this systematic review, literature from Medline via (PubMed, Ovid) Embase, Scopus, Cochrane Library, and ProQuest between 1988 and 2020 were included. A combination of Mesh and free terms were included in the search strategy: &ldquo;Stroke&rdquo;, &ldquo;Red Cell Distribution Width&rdquo;, &ldquo;Blood Cell Count&rdquo;, &ldquo;Mean corpuscular hemoglobin&rdquo;, and &ldquo;Mean Corpuscular Volume&rdquo; and with the abbreviation, in all fields. Data synthesis was achieved using content analysis.<br> <strong>Results</strong>: Elevated red blood cell distribution width was associated with stroke, cardiovascular events, and all-cause deaths among patients with prior stroke. Mean platelet volume has not any prognostic significance in ischemic stroke. There was a poor association between mean corpuscular volume (MCV) and stroke prognosis. Globulin and hemoglobin level predicted short-term mortality following acute ischemic stroke.<br> <strong>Conclusion</strong>: Complete blood count as a routine and efficient test performed in health care centers can be used to estimate the prognosis of stroke.<br> <span style="font-size:11pt"><span style="line-height:150%"><span sans-serif="" style="font-family:Calibri,"><span style="font-family:"Times New Roman","serif""></span></span></span></span></div> Stroke, Erythrocyte indices, Blood cell count, Prognosis 745 754 http://bcn.iums.ac.ir/browse.php?a_code=A-10-2168-2&slc_lang=en&sid=1 Samad Shams Vahdati sshamsv@gmail.com 13700319475328460043497 13700319475328460043497 No Emergency Medicine Research Team, Tabriz University of Medical Sciences, Tabriz, Iran. Alireza Ala ala.alireza@gmail.com 13700319475328460043498 13700319475328460043498 No Emergency Medicine Research Team, Tabriz University of Medical Sciences, Tabriz, Iran. Nafiseh Vahed vahedn66@gmail.com 13700319475328460043499 13700319475328460043499 Yes Research Center for Evidence Based Medicine, Tabriz University of Medical Sciences, Tabriz, Iran. Sahar Mohammadi sahar_mohammadi96@yahoo.com 13700319475328460043500 13700319475328460043500 No Department of Emergency Medicine, Faculty of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran. Hoorolnesa Ameli h.med81@yahoo.com 13700319475328460043501 13700319475328460043501 No Clinical Research Development Center, Shahid Beheshti Hospital, Qom University of Medical Sciences, Qom, Iran.