en Clinical Neuroscience Clinical Neuroscience Original Original <p align="left"><b><font color="#221e1f" size="2"><font color="#221e1f" size="2">Introduction: </font></font><font color="#221e1f" size="2" face="Times New Roman,Times New Roman"><font color="#221e1f" size="2" face="Times New Roman,Times New Roman"><font color="#221e1f" size="2" face="Times New Roman,Times New Roman">This study was designed to investigate the effects of music in Wistar rats after sub-chronic treatment of simvastatin. </font></font></font><b><font color="#221e1f" size="2"><font color="#221e1f" size="2"></font></font><font color="#221e1f" size="2" face="Times New Roman,Times New Roman"><font color="#221e1f" size="2" face="Times New Roman,Times New Roman"><font color="#221e1f" size="2" face="Times New Roman,Times New Roman">The rats were orally administered with either simvastatin or saline (controls). After 4 weeks of drug treatment, the rats were selected for behavioral studies. The rats were exposed to music 24 hours before behavioral tests (Mozart’s piano sonata, KV361, Largo). </font></font></font><b><font color="#221e1f" size="2"><font color="#221e1f" size="2"><p align="justify">Results: </p></font></font><font color="#221e1f" size="2" face="Times New Roman,Times New Roman"><font color="#221e1f" size="2" face="Times New Roman,Times New Roman"><font color="#221e1f" size="2" face="Times New Roman,Times New Roman">The experiments suggest that exposure to chronic treatment with simvastatin (1 or 10 mg/kg/day) reduced anxiety levels in rats when associated with Mozart music in an elevated plus-maze. </font></font></font><b><font color="#221e1f" size="2"><font color="#221e1f" size="2"><p>Discussion: </p></font></font><font color="#221e1f" size="2" face="Times New Roman,Times New Roman"><font color="#221e1f" size="2" face="Times New Roman,Times New Roman"><font color="#221e1f" size="2" face="Times New Roman,Times New Roman">These results indicate that music can serve as an effective adjuvant in rats treated with simvastatin, and that this species could potentially be used in other preclinical models utilizing musical interventions. </font></font></font></b></b></b></b><p></p></p><p align="justify">Methods: </p> Music,Elevated plus-maze,Open-field,Rattus norvegicus,Simvastatin. 5 11 http://bcn.iums.ac.ir/browse.php?a_code=A-10-1-70&slc_lang=en&sid=1 Júlia Niehues da Cruz 1370031947532846001181 1370031947532846001181 No Universidade do Extremo Sul Catarinense, Santa Catarina, Brazil Daniela Delwing de Lima 1370031947532846001182 1370031947532846001182 No Universidade da Região de Joinville, Santa Catarina, Brazil Débora Delwing Dal Magro 1370031947532846001183 1370031947532846001183 No Universidade Regional de Blumenau, Santa Catarina, Brazil José Geraldo Pereira da Cruz 1370031947532846001184 1370031947532846001184 Yes Department of Natural Sciences, Universidade Regional de Blumenau, Santa Catarina, Brazil