Basic and Clinical Neuroscience Journal
مجله علوم اعصاب پایه و بالینی
BCN
Medical Sciences
http://bcn.iums.ac.ir
137
journal137
2008-126X
2228-7442
10.32598/bcn
en
jalali
1400
6
1
gregorian
2021
9
1
12
5
online
1
fulltext
en
A Neurochemical and Electrophysiological Study on the Combined Effects of Caffeine and Nicotine in the Cortex of Rats
Cellular and molecular Neuroscience
Cellular and molecular Neuroscience
Original
Original
<div style="text-align: justify;"><strong>Introduction</strong>: Caffeine and nicotine are the most widely consumed psychostimulants worldwide. Although the effects of each drug alone on the central nervous system have been studied extensively, the literature on the neurochemical and electrophysiological effects of their combined treatments is scarce. The present study investigated the cortical electrophysiological and neurochemical alterations induced by acute administration of caffeine and nicotine in rats. <br>
<strong>Methods</strong>: The rats received caffeine and nicotine at a 1-hour interval between the two treatments. <br>
<strong>Results</strong>: Caffeine and nicotine administration resulted in a significant decrease in the concentrations of cortical amino acid neurotransmitters, namely glutamate, aspartate, glycine, and taurine, while γ-aminobutyric acid (GABA) significantly increased. Increased cortical lipid peroxidation and reduced glutathione and nitric oxide levels and acetylcholinesterase and Na⁺/K⁺-ATPase activities were also observed. The Electroencephalogram (EEG) showed an increase in delta frequency power band, whereas theta, beta-1, and beta-2 decreased after caffeine and nicotine treatment. <br>
<strong>Conclusion</strong>: These findings suggest that caffeine and nicotine adversely exacerbate their stimulant effects manifested by the EEG changes mediated by increasing cholinergic transmission and disturbing the balance between the excitatory and inhibitory amino acids leading to oxidative stress.</div>
Caffeine, Nicotine, Electroencephalogram, Oxidative stress, Amino acid neurotransmitters
681
692
http://bcn.iums.ac.ir/browse.php?a_code=A-10-2100-1&slc_lang=en&sid=1
Iman M.
Mourad
emanmourad@rocketmail.com
13700319475328460039414
13700319475328460039414
No
Department of Zoology, School of Science, Cairo University, Egypt.
Neveen A.
Noor
emanmourad@rocketmail.com
13700319475328460039415
13700319475328460039415
No
Department of Zoology, School of Science, Cairo University, Egypt.
Haitham S.
Mohammed
haitham_sharaf@yahoo.com
13700319475328460039416
13700319475328460039416
No
Department of Biophysics, School of Science, Cairo University, Egypt.
Heba S.
Aboul Ezz
hebasal@yahoo.com
13700319475328460039417
13700319475328460039417
No
Department of Zoology, School of Science, Cairo University, Egypt.
Yasser A.
Khadrawy
yaserask@yahoo.com
13700319475328460039418
13700319475328460039418
Yes
Department of Medical Physiology, Medical Division, National Research Center, Egypt.