Basic and Clinical Neuroscience Journal
مجله علوم اعصاب پایه و بالینی
BCN
Medical Sciences
http://bcn.iums.ac.ir
137
journal137
2008-126X
2228-7442
10.32598/bcn
en
jalali
1399
12
1
gregorian
2021
3
1
12
2
online
1
fulltext
en
Minocycline Mitigation of Tremor Syndrome and Defect of Cognitive and Balance Induced by Harmaline
Behavioral Neuroscience
Behavioral Neuroscience
Original
Original
<div style="text-align: justify;"><strong>Introduction</strong>: Minocycline has anti-inflammatory, anti-apoptotic, and anti-oxidant effects. Preclinical data suggest that minocycline could be beneficial for treating common neurological disorders, including Parkinson disease and multiple sclerosis.<br>
<strong>Methods</strong>: In this study, the effects of minocycline on harmaline-induced motor and cognitive impairments were studied in male Wistar rats. The rats were divided into four groups of ten animals each. Harmaline was used for the induction of Essential Tremor (ET). Minocycline (90 mg/kg, IP) was administered 30 minutes before the saline or harmaline. Tremor intensity, spontaneous locomotor activity, passive avoidance memory, anxiety-related behaviors, and motor function were assessed in the rats. <br>
<strong>Results</strong>: The results showed that minocycline could recover tremor intensity and step width but failed to recuperate the motor balance. The memory impairments observed in harmaline-treated rats were somewhat reversed by administration of minocycline. The cerebellum and inferior olive nucleus were studied for neuronal degeneration using histochemistry and transmission electron microscopy techniques. Harmaline caused ultrastructural changes and neuronal cell loss in inferior olive and cerebellar Purkinje cells. Minocycline exhibited neuroprotective changes on cerebellar Purkinje cells and inferior olivary neurons.<br>
<strong>Conclusion</strong>: These results open new therapeutic perspectives for motor and memory impairments in ET. However, further studies are needed to clarify the exact mechanisms.</div>
Essential tremor, Minocycline, Motor skills, Memory
255
268
http://bcn.iums.ac.ir/browse.php?a_code=A-10-1980-1&slc_lang=en&sid=1
Marzieh
Maneshian
13700319475328460034007
13700319475328460034007
No
Department of Physiology, Physiological Research Center, Iran University of Medical Sciences, Tehran, Iran.
Farinaz
Nasirinezhad
13700319475328460034008
13700319475328460034008
No
Department of Physiology, Physiological Research Center, Iran University of Medical Sciences, Tehran, Iran.
Fatemeh
Mohammadi
13700319475328460034009
13700319475328460034009
No
Intracellular Recording Lab, Neuroscience Research Center, Neuropharmacology Institute, Kerman University of Medical Sciences, Kerman, Iran.
Mina
Behzadi
13700319475328460034010
13700319475328460034010
No
Intracellular Recording Lab, Neuroscience Research Center, Neuropharmacology Institute, Kerman University of Medical Sciences, Kerman, Iran.
Majid
Asadi-Shekaari
13700319475328460034011
13700319475328460034011
No
Intracellular Recording Lab, Neuroscience Research Center, Neuropharmacology Institute, Kerman University of Medical Sciences, Kerman, Iran.
Mohammad
Shabani
habani@kmu.ac.ir
13700319475328460034012
13700319475328460034012
Yes
Intracellular Recording Lab, Neuroscience Research Center, Neuropharmacology Institute, Kerman University of Medical Sciences, Kerman, Iran.