Basic and Clinical Neuroscience Journal
مجله علوم اعصاب پایه و بالینی
BCN
Medical Sciences
http://bcn.iums.ac.ir
137
journal137
2008-126X
2228-7442
10.32598/bcn
en
jalali
1400
8
1
gregorian
2021
11
1
12
6
online
1
fulltext
en
The Association Between Fennel Extract, Serum Lipid Profile, and Leptin Receptor Expression
Cellular and molecular Neuroscience
Cellular and molecular Neuroscience
Original
Original
<div style="text-align: justify;"><strong>Introduction: </strong>Obesity is among the most severe challenges of our era, with significant health consequences and a high economic burden for health systems. Therefore, many countries have developed political agendas to cope with this ever-rising challenge. Along with chemical medications developed to manage obesity, researchers have focused on some natural ingredients and herbal extracts that are effective in reducing weight. The current study investigated the association between Foeniculum vulgar (fennel) extracts and body weight, lipid profile, and leptin. <br>
<strong>Methods:</strong> In total, 35 adult male BALB/c mice were investigated in sham, fennel 50 mg/kg, fennel 100 mg/kg, and fennel 200 mg/kg (n=7) groups. The mice were administered fennel extracts for fourteen days while weighted at the intervention’s beginning and end. Then, their weight, lipid profile, serum leptin, and expression of leptin protein in the hypothalamus were measured.<br>
<strong>Results:</strong> After providing the intervention, leptin receptor protein expression was increased in all groups, while serum leptin didn’t change significantly. Moreover, a significant decrease was observed in the cholesterol dose of 100 mg/kg/day, triglycerides in 100 and 200 mg/kg/day, and LDL in 50 and 100 mg/kg/day. Serum HDL was increased significantly in a dose of 100 mg/kg/day. <br>
<strong>Conclusion:</strong> Fennel extract can decrease the lipid profile by changing the expression of the leptin receptor.</div>
Fennel, Foeniculum vulgare, Lipid profile, Leptin, Hypothalamus, Obesity
711
720
http://bcn.iums.ac.ir/browse.php?a_code=A-10-998-2&slc_lang=en&sid=1
Forogh
Zakernezhad
zakernezhad_forogh@yahoo.com
13700319475328460039333
13700319475328460039333
No
Department of Cellular and Molecular Biology, Tehran North Branch, Islamic Azad University, Tehran, Iran.
Mahmood
Barati
mahmood.barati@gmail.com
13700319475328460039334
13700319475328460039334
No
Department of Biotechnology, School of Allied Medicine, Iran University of Medical Science, Tehran, Iran.
Nima
Sanadgol
sanadgol.n@gmail.com
13700319475328460039335
13700319475328460039335
No
Department of Biology, School of Sciences, University of Zabol, Zabol, Iran.
Monireh
Movahhedi
mon_movahedi@yahoo.com
13700319475328460039336
13700319475328460039336
No
Department of Cellular and Molecular Biology, Tehran North Branch, Islamic Azad University, Tehran, Iran.
Ahmad
Majd
ahmad_majd2005@yahoo.com
13700319475328460039337
13700319475328460039337
No
Department of Cellular and Molecular Biology, Tehran North Branch, Islamic Azad University, Tehran, Iran.
Fereshteh
Golab
fgolab520@gmail.com
13700319475328460039338
13700319475328460039338
Yes
Cellular and Molecular Research Center, Iran University of Medical Sciences, Tehran, Iran.