Basic and Clinical Neuroscience Journal
مجله علوم اعصاب پایه و بالینی
BCN
Medical Sciences
http://bcn.iums.ac.ir
137
journal137
2008-126X
2228-7442
10.32598/bcn
en
jalali
1401
12
1
gregorian
2023
3
1
14
2
online
1
fulltext
en
Brain Atrophy and Physical and Cognitive Disability in Multiple Sclerosis
Clinical Neuroscience
Clinical Neuroscience
Original
Original
<div style="text-align: justify;"><strong>Introduction</strong>: Brain atrophy is associated with physical disability in multiple sclerosis (MS), but there is a great variability between different studies and methodologies, and its use is still limited to research projects. We aimed to analyze the relationship between several volumetric measurements and physical disability and cognitive functioning in MS patients in a clinical practice setting. <br>
<strong>Methods</strong>: This is a cross-sectional study. A total of 41 patients (31 relapsing-remitting MS, 6 secondary-progressive MS, and 4 primary-progressive MS) were included. Whole brain volume (WBV), gray matter volume (GMV), and T2 lesion load (T2L) were obtained using Icometrix® software. Physical disability was measured with the Expanded Disability Status Scale (EDSS), and cognitive status was evaluated with the brief repeatable battery of neuropsychological tests (BRB-N). The relationship between brain volumes and EDSS was analyzed through linear multivariate regression. The association between volumetry measurements and the number of affected cognitive domains was studied with negative binomial regression.<br>
<strong>Results</strong>: GMV was associated with age (b=-1.7, p=0.014) and with EDSS (b=-7.55, p=0.013). T2L was associated with EDSS (b=2.29, p=0.032). The number of affected cognitive domains was associated with clinical phenotype, worse in primary progressive MS (PPMS). There was not correlations between cognitive impairment and cerebral volumes.<br>
<strong>Conclusion</strong>: Brain atrophy measurement is feasible in clinical practice setting, and it is helpful in monitoring the EDSS progression. Primary progressive phenotype is associated with greater risk of cognitive dysfunction.</div>
Brain atrophy, Cognitive dysfunction, Multiple sclerosis, Disease progression, Magnetic resonance imaging
311
316
http://bcn.iums.ac.ir/browse.php?a_code=A-10-1893-1&slc_lang=en&sid=1
Luis Ignacio Casanova
Peño
licasanova@torrejonsalud.com
13700319475328460045272
13700319475328460045272
Yes
Department of Neurology, Torrejón University Hospital, Madrid, Spain.
Carlos López De Silanes
De Miguel
13700319475328460045273
13700319475328460045273
No
Department of Neurology, Torrejón University Hospital, Madrid, Spain.
Laura
de Torres
13700319475328460045274
13700319475328460045274
No
Department of Neurology, Torrejón University Hospital, Madrid, Spain.
Miriam Eimil
Ortiz
13700319475328460045275
13700319475328460045275
No
Department of Neurology, Torrejón University Hospital, Madrid, Spain.
María José Gil
Moreno
13700319475328460045276
13700319475328460045276
No
Department of Neurology, Torrejón University Hospital, Madrid, Spain.
Beatriz Oyanguren
Rodeño
13700319475328460045277
13700319475328460045277
No
Department of Neurology, Torrejón University Hospital, Madrid, Spain.
Rodrigo Terrero
Carpio
13700319475328460045278
13700319475328460045278
No
Department of Neurology, Torrejón University Hospital, Madrid, Spain.
Julia Sabín
Muñoz
13700319475328460045279
13700319475328460045279
No
Department of Neurology, Torrejón University Hospital, Madrid, Spain.
Blanca Patricia Díaz
Montoya
13700319475328460045280
13700319475328460045280
No
Department of Neurology, Torrejón University Hospital, Madrid, Spain.
Miguel Ángel Saiz
Sepúlveda
13700319475328460045281
13700319475328460045281
No
Department of Neurology, Torrejón University Hospital, Madrid, Spain.
Esther De
Antonio Sanz
13700319475328460045282
13700319475328460045282
No
Department of Radiology, Torrejón University Hospital, Madrid, Spain.
Sara
Abellán Ayuso
13700319475328460045283
13700319475328460045283
No
Department of Neurology, Torrejón University Hospital, Madrid, Spain.
Marta González
Salaices
13700319475328460045284
13700319475328460045284
No
Department of Neurology, Torrejón University Hospital, Madrid, Spain.