en Computational Neuroscience Computational Neuroscience Original Original <div style="text-align: justify;">One of the interesting topics in neuroscience is problem solving and decision-making. In this area, everything gets more complicated when events occur sequentially. One of the practical methods for handling the complexity of brain function is to create an empirical model. Model Predictive Control (MPC) is known as a powerful mathematical-based tool often used in industrial environments. We proposed an MPC and its algorithm as a part of the functionalities of the brain to improve the performance of the decision-making process. It is well known that the decision-making process results from communication between the prefrontal cortex (working memory) and hippocampus (long-term memory). However, there are other regions of the brain that play essential roles in making decisions, but their exact mechanisms of action still are unknown. In this study, we modeled those mechanisms with MPC. We showed that MPC controls the stream of data between prefrontal cortex and hippocampus in a closed-loop system to correct actions.</div> Decision-making process, Model predictive control, Memory structure, Prefrontal cortex, Hippocampus 443 450 http://bcn.iums.ac.ir/browse.php?a_code=A-10-1849-2&slc_lang=en&sid=1 Sohrab Saberi Moghadam sohrab.saberimoghadam@gmail.com 13700319475328460024302 13700319475328460024302 Yes Faculty of Engineering Modern Technologies, Amol University of Special Modern Technologies, Amol, Iran. Farid Samsami Khodadad samsami@ausmt.ac.ir 13700319475328460024303 13700319475328460024303 No Faculty of Engineering Modern Technologies, Amol University of Special Modern Technologies, Amol, Iran. Vahid Khazaeinezhad vahid.khazaeinezhad@gmail.com 13700319475328460024304 13700319475328460024304 No Department of Computer Engineering, Faculty of Engineering, Ayatollah Amoli Branch, Islamic Azad University, Amol, Iran.