en Clinical Neuroscience Clinical Neuroscience News and Reports News and Reports <strong>Background</strong>: Myxoma may cause systemic embolization and frequently presents as ischemic stroke.&nbsp;<br> <strong>Case Presentation</strong>: There have been debates about whether it is safe to use recombinant tissue plasminogen activator (rt-PA) in patients with cardiac myxoma who referred with ischemic stroke to the hospital&#39;s emergency.&nbsp;<br> <strong>Results</strong>: The patient was a young case of atrial myxoma with initial presentation of acute cerebral infarction symptoms who was treated with intravenous rt-PA with no complications.<br> <strong>Conclusion</strong>: The case provides an evidence of the efficacy and safety of intravenous rt-PA in cases of cardiac myxoma. However, we cannot always expect thrombolytic therapy to be effective, especially in tumor emboli. Cardiac myxoma, Acute ischemic stroke, rt-PA, IV-thrombolysis, Stroke 855 860 http://bcn.iums.ac.ir/browse.php?a_code=A-10-1844-1&slc_lang=en&sid=1 Sara Esmaeili sara.es64@gmail.com 13700319475328460032229 13700319475328460032229 No Department of Neurology, Cellular and Molecular Research Center, Firoozgar Hospital, Student Research Committee, Iran University of Medical Sciences, Tehran, Iran. Seyedeh Fahimeh Shojaei shojaee.fahimeh@yahoo.com 13700319475328460032230 13700319475328460032230 No Firoozgar Clinical Research and Development Center (FCRDC), Iran University of Medical Sciences, Tehran, Iran. Maryam Bahadori maryam.bahadori.1987@gmail.com 13700319475328460032231 13700319475328460032231 No Department of Neurology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran. Mohammad Mojtahed 13700319475328460032232 13700319475328460032232 No Department of Neurology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran. Masoud Mehrpour dr.masoudmehrpour@gmail.com 13700319475328460032233 13700319475328460032233 Yes Department of Neurology, School of Medicine, Firoozgar Hospital, Iran University of Medical Sciences, Tehran, Iran.