Basic and Clinical Neuroscience Journal
مجله علوم اعصاب پایه و بالینی
BCN
Medical Sciences
http://bcn.iums.ac.ir
137
journal137
2008-126X
2228-7442
10.32598/bcn
en
jalali
1399
10
1
gregorian
2021
1
1
12
1
online
1
fulltext
en
Comparing the Effects of Melatonin and Zolpidem on Sleep Quality, Depression, and Anxiety in Patients With Colorectal Cancer Undergoing Chemotherapy
Clinical Neuroscience
Clinical Neuroscience
Original
Original
<strong>Introduction</strong>: Patients with cancer may have many complications involving their psychosomatic systems, such as sleep disturbance, depression, and anxiety. Thus, many research studies were conducted to reduce these complications. Zolpidem, as a short-term non-benzodiazepine treatment of insomnia, and melatonin as a chronobiological function-regulatory hormone, are commonly used for improving sleep quality. This randomized clinical trial aims to compare the effects of zolpidem and melatonin on sleep quality, depression, and anxiety in patients with colorectal cancer.<br>
<strong>Methods</strong>: In this single-blinded trial, 90 patients with colorectal cancer undergoing chemotherapy who had obtained a score of 5 or higher on the Pittsburgh Sleep Quality Index (PSQI) were randomly divided into two groups (n=45). One group was treated with 10 mg zolpidem at bedtime, and the other group received 6 mg melatonin at bedtime for 30 days. PSQI on weeks 0, 4, 8, Groningen sleep quality scale, Hamilton rating scale for depression, and Hamilton anxiety rating scale questionnaires were performed to assess patients on weeks 0, 4, and 8. The outcome was then analyzed, and P≤0.05 was considered statistically significant.<br>
<strong>Results</strong>: Both zolpidem and melatonin had significant impacts on sleep quality in week 4 (P<0.05). After stopping the treatments, the conditions were noticeably reversed on week 8 (P<0.05). Zolpidem and melatonin were relatively similar in affecting sleep duration, latency, efficiency, and disturbance. None of the two study medications had any considerable influence on anxiety and depression.<br>
<strong>Conclusion</strong>: Melatonin and zolpidem are promising agents for treating sleep complications and, to some extent, depression, and anxiety in cancer patients, according to the present study. However, further clinical trials are recommended to confirm the results of this study.
Neoplasms, Sleep initiation and maintenance disorders, Depression, Anxiety, Zolpidem, Melatonin
105
114
http://bcn.iums.ac.ir/browse.php?a_code=A-10-1650-2&slc_lang=en&sid=1
Maryam
Shahrokhi
shahrokhi.mail85@mail85.com
13700319475328460031849
13700319475328460031849
No
Department of Clinical Pharmacy, Faculty of Pharmacy, Guilan University of Medical Sciences, Rasht, Iran.
Padideh
Ghaeli
pghaeli@sina.tums.ac.ir
13700319475328460031850
13700319475328460031850
No
Department of Clinical Pharmacy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.
Pantea
Arya
dr.aryaapantea@gmail.com
13700319475328460031851
13700319475328460031851
No
Department of Psychiatry, Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Alia
Shakiba
alia_shakiba@yahoo.com
13700319475328460031852
13700319475328460031852
No
Psychiatry and Psychoogy Research Center, Roozbeh Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Afsaneh
Noormandi
yalda.nor@gmail.com
13700319475328460031853
13700319475328460031853
No
Department of Clinical Pharmacy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.
Mehdi
Soleimani
msoleimani@sina.tums.ac.ir
13700319475328460031854
13700319475328460031854
No
Department of Psychiatry, Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Mohsen
Esfandbod
esfandbod@sina.ac.ir
13700319475328460031855
13700319475328460031855
Yes
Hematology-Oncology and Stem Cell Research Center, Tehran University of Medical Sciences, Tehran, Iran.