en Clinical Neuroscience Clinical Neuroscience Original Original <b><font color="#211d1e" size="2"><font color="#211d1e" size="2"><p align="left">Introduction: </p></font></font><font color="#211d1e" size="2" face="Times New Roman,Times New Roman"><font color="#211d1e" size="2" face="Times New Roman,Times New Roman"><font color="#211d1e" size="2" face="Times New Roman,Times New Roman">Hyperalgesia is considered as one of the marked signs of subchronic diabetes mellitus in patients that could affect their lifestyle. This study was designed to investigate the anti-nociceptive effect of chronic administration of quercetin in </font></font></font><font color="#211d1e" size="2" face="Times New Roman,Times New Roman"><font color="#211d1e" size="2" face="Times New Roman,Times New Roman"><font color="#211d1e" size="2" face="Times New Roman,Times New Roman">streptozotocin (STZ)-diabetic rats using formalin and hot tail immersion tests. </font></font></font><b><font color="#211d1e" size="2"><font color="#211d1e" size="2"><p align="left">Methods: </p></font></font><font color="#211d1e" size="2" face="Times New Roman,Times New Roman"><font color="#211d1e" size="2" face="Times New Roman,Times New Roman"><font color="#211d1e" size="2" face="Times New Roman,Times New Roman">Rats were divided into control, control or diabetic groups receiving sodium salicylate, untreated diabetic, and quercetin-treated control and diabetic groups. The treatment groups received i.p. administration of quercetin at a dose of 10 mg/kg for 6 weeks. Finally, hyperalgesia were assessed using standard formalin </font></font></font><font color="#211d1e" size="2" face="Times New Roman,Times New Roman"><font color="#211d1e" size="2" face="Times New Roman,Times New Roman"><font color="#211d1e" size="2" face="Times New Roman,Times New Roman">and hot tail immersion tests. Meanwhile, some markers of oxidative stress were </font></font></font><font color="#211d1e" size="2" face="Times New Roman,Times New Roman"><font color="#211d1e" size="2" face="Times New Roman,Times New Roman"><font color="#211d1e" size="2" face="Times New Roman,Times New Roman">also measured in brain tissue.</font></font></font><b><font color="#211d1e" size="2"><font color="#211d1e" size="2"><p align="left">Results: </p></font></font><font color="#211d1e" size="2" face="Times New Roman,Times New Roman"><font color="#211d1e" size="2" face="Times New Roman,Times New Roman"><font color="#211d1e" size="2" face="Times New Roman,Times New Roman">Quercetin or SS treatment of diabetic rats significantly reduced pain score in chronic phase of formalin test (p<0.05). Regarding hot tail immersion test, diabetic rats showed a significant reduction in tail flick latency as compared to control ones (p<0.05) and quercetin treatment of diabetic rats did significantly increase this latency relative to untreated diabetics (p<0.05). Quercetin treatment of diabetic rats also significantly decreased brain level of malondialdehyde (MDA) (p<0.05) and nitrite (p<0.05) and slightly increased activity of superoxide dismutase (SOD) relative to diabetics. </font></font></font><b><font color="#211d1e" size="2"><font color="#211d1e" size="2"><p align="left">Discussion: </p></font></font><font color="#211d1e" size="2" face="Times New Roman,Times New Roman"><font color="#211d1e" size="2" face="Times New Roman,Times New Roman"><font color="#211d1e" size="2" face="Times New Roman,Times New Roman">Taken together, chronic administration of quercetin could attenuate nociceptive score in chronic phase of formalin test in streptozotocin-diabetic rats and could also increase threshold of thermal nociception.</font></font></font><p align="left">　</p><p align="left">　</p></b></b></b></b> Quercetin,Diabetes Mellitus,Antinociception,Formalin Test,Hot Tail Immersion Test,Oxidative Stressof 51 57 http://bcn.iums.ac.ir/browse.php?a_code=A-10-1-64&slc_lang=en&sid=1 Jamshid Narenjkar 137003194753284600967 137003194753284600967 Yes Mehrdad Roghani 137003194753284600968 137003194753284600968 No Hanieh Alambeygi 137003194753284600969 137003194753284600969 No Farnoosh Sedaghati 137003194753284600970 137003194753284600970 No