en Cellular and molecular Neuroscience Cellular and molecular Neuroscience Letter to Editor Letter to Editor <div style="text-align: justify;">In this Correspondence, a comment to a recent paper by Nikbakht et al., published in the latest ssu of this Journal is reported. The flavone apigenin can exert both its anti-oxidant potetial via the usual enzymatic ROS scavenging system and the mitochondria biogenesis via the PGC-1&alpha;/ TFAM/NRF-1 pathway. The very interesting paper by Nikbakht et al, may earn more insighful clues about the activity of apigenin in the prevention of the rat hippocampus neuronal loss caused by the A&beta;25-35 injection.</div> Rat, Apigenin, Neuronal loss, Mitochondria, Biogenesis, PGC-1alpha 541 544 http://bcn.iums.ac.ir/browse.php?a_code=A-10-1700-2&slc_lang=en&sid=1 Salvatore Chirumbolo salvatore.chirumbolo@univr.it 13700319475328460025462 13700319475328460025462 Yes Department of Neuroscience, Biomedicine and Movement Sciences, Unit of Human Anatomy, University of Verona, Verona, Italy.