en Behavioral Neuroscience Behavioral Neuroscience Original Original <div style="text-align: justify;"><strong>Introduction</strong>: The central-governor model explains the mechanism of endurance exercise-induced central fatigue, but high-intensity exercise-induced central fatigue has not been investigated yet. This study aimed to research how central fatigue during high-intensity intermittent pedaling alters the neural response, which results in electroencephalography (EEG) recordings.<br> <strong>Methods</strong>: We assessed neural response by measuring the alternation of brainwave spectral power during an intermittent high-intensity 60-minute exercise on an ergometer cycle. The cadences were changed every 10 minutes according to intermittent pattern altering (90-120-60-120-60-90 rpm). EEG was used to analyze altering brain function. Heart rate (HR), blood lactate (BL), and rating of perceived exertion (RPE) were measured after the change in cadences.<br> <strong>Results</strong>: HR, BL, and RPE increased at a cadence of 120 rpm compared with 60 rpm on the ergometer cycle. The spectral power of EEG, according to cadence &times; brainwaves, significantly increased (P˂0.01) in the alpha and beta frequency ranges with a change in cadences between 60 rpm and 120 rpm. The spectral power of the EEG significantly increased (P˂0.01) over the whole frequency range from rest to warming (theta: 251%, alpha: 165%, beta: 145%) and significantly reduced in theta, alpha, and beta (theta: 176%, alpha: 142%, beta: 77%) (P&le;0.01).<br> <strong>Conclusion</strong>: High-intensity exercises (90 and 120 cadences) increased brain function, regardless of fatigue occurrence. High-intensity interval training (HIIT) led to altering the neural response. It would be required to investigate the usefulness of HIIT to treat some of the psychotic disorders.</div> <span class="rangySelectionBoundary" id="selectionBoundary_1551592955198_1522745107664485" style="line-height: 0; display: none;"></span> Electroencephalography, Central fatigue, High-intensity interval training 631 640 http://bcn.iums.ac.ir/browse.php?a_code=A-10-1513-1&slc_lang=en&sid=1 Mehrangiz Ghorbani mehrqorbani1@gmail.com 13700319475328460026190 13700319475328460026190 Yes Department of Physical Education and Sport Sciences, Faculty of Humanities and Social Sciences, Science and Research Branch, Islamic Azad University, Tehran, Iran. & Department of Physical Education and Sport Sciences, Bijar Branch, Islamic Azad University, Bijar, Iran. Farshad Ghazalian mehrqorbani1@gmail.com 13700319475328460026191 13700319475328460026191 No Department of Physical Education and Sport Sciences, Faculty of Humanities and Social Sciences, Science and Research Branch, Islamic Azad University, Tehran, Iran. Khosrow Ebrahim mehrqorbani1@gmail.com 13700319475328460026192 13700319475328460026192 No Department of Physical Education and Sport Sciences, Faculty of Humanities, Shahid Beheshti University, Tehran, Iran. Hossein Abednatanzi mehrqorbani1@gmail.com 13700319475328460026193 13700319475328460026193 No Department of Physical Education and Sport Sciences, Faculty of Humanities and Social Sciences, Science and Research Branch, Islamic Azad University, Tehran, Iran.