en Clinical Neuroscience Clinical Neuroscience Original Original <div style="text-align: justify;"><strong>Introduction: </strong>Oxidative stress has recently emerged as a possible mechanism in the pathogenesis of epilepsy. Coenzyme Q10 (CoQ10) is a strong endogenous antioxidant that protects cells from lipid oxidation and Reactive Oxygen Species (ROS) production; however, the impact of CoQ10 on seizure characteristics in epileptic patients is unclear.<br> <strong>Methods:</strong> The current study enrolled patients with Epileptic Seizure (ES) to evaluate their serum concentration of CoQ10 and to investigate whether a relationship exists between CoQ10 levels with the duration, frequency, and type of seizure.&nbsp;<br> <strong>Results:</strong> A total of 39 patients with epileptic seizures and 35 healthy controls were included in the study. The levels of CoQ10 in ES patients were significantly lower in comparison with healthy controls (11.99&plusmn;5.93 vs (ng/ml). 16.48&plusmn;4.20 (ng/ml) P<0.001). We also found that the duration of epilepsy and seizure frequency was negatively correlated with serum CoQ10 levels.<br> <strong>Conclusion:</strong> These findings indicate that CoQ10 deficiency might substantially contribute to the clinical signs of epileptic patients.</div> Coenzyme Q10, Epileptic seizures, Oxidative stress, Clinical signs of seizure 765 772 http://bcn.iums.ac.ir/browse.php?a_code=A-10-1100-1&slc_lang=en&sid=1 Leila Simani l.simani90@sbmu.ac.ir 13700319475328460030685 13700319475328460030685 Yes Skull Base Research Center, Loghman Hakim Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Omidvar Rezaei dromidvarrezaee@gmail.com 13700319475328460030686 13700319475328460030686 No Skull Base Research Center, Loghman Hakim Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Fari Ryan Fari.ryan@mail.mcgill.ca 13700319475328460030687 13700319475328460030687 No Centre for Research in Neuroscience, The Research Institute of the McGill University Health Center, Montreal, Quebec, Canada Masoumeh Sadeghi sadeghi.masoume@gmail.com 13700319475328460030688 13700319475328460030688 No Department of Epidemiology, School of Public Health and Safety, Shahid Beheshti University of Medical Sciences, Tehran, Iran Etrat Hooshmandi ehoshmandi@gmail.com 13700319475328460030689 13700319475328460030689 No Clinical Neurology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran. Mahtab Ramezani drramezani96@gmail.com 13700319475328460030690 13700319475328460030690 No Skull Base Research Center, Loghman Hakim Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Hossin Pakdaman hpakdaman20@yahoo.com 13700319475328460030691 13700319475328460030691 No Brain Mapping Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.