Basic and Clinical Neuroscience Journal
مجله علوم اعصاب پایه و بالینی
BCN
Medical Sciences
http://bcn.iums.ac.ir
137
journal137
2008-126X
2228-7442
10.32598/bcn
en
jalali
1398
4
1
gregorian
2019
7
1
10
4
online
1
fulltext
en
Introducing Genes With Significant Role in Migraine: An Interactomic Approach
Behavioral Neuroscience
Behavioral Neuroscience
Original
Original
<div style="text-align: justify;"><strong>Introduction</strong>: Migraine is a severe kind of headache with the chance hereditary of 50%. Molecular studies can promote understanding of migraine pathophysiology. One of which is bioinformatics approach that could provide additional information related to the identified biomarkers. <br>
<strong>Methods</strong>: In this research, migraine genes are studies in terms of interaction pattern to introduce important individuals. Through STRING database Plug-in in Cytoscape, candidate genes for migraine were retrieved and analyzed by related applications. Based on centrality and action types (expression, activation, and inhibition) genes were screened. <br>
<strong>Results</strong>: Numbers of 33 central genes including seven hub-bottlenecks were identified which 70% of central genes were involved in expression action with each other. Activation was dominate action relative to inhibition between the central genes.<br>
<strong>Conclusion</strong>: The finding indicates that insulin is the most important gene relative to migraine. It seems regulation of metabolism play critical role in control of migraine. </div>
Migraine disorders, Protein interaction maps, Genes
363
372
http://bcn.iums.ac.ir/browse.php?a_code=A-10-941-5&slc_lang=en&sid=1
Mona
Zamanian-Azodi
mona.azodi@gmail.com
13700319475328460021242
13700319475328460021242
Yes
Student Research Committee, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Mostafa
Rezaei-Tavirani
tavirany@yahoo.com
13700319475328460021243
13700319475328460021243
No
Proteomics Research Center, Faculty of Paramedical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Reza Mahmoud
Robati
mrobati@gmail.com
13700319475328460021244
13700319475328460021244
No
Skin Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.