en Behavioral Neuroscience Behavioral Neuroscience Original Original <div style="text-align: justify;"><strong>Introduction</strong>: Migraine is a severe kind of headache with the chance hereditary of 50%. Molecular studies can promote understanding of migraine pathophysiology. One of which is bioinformatics approach that could provide additional information related to the identified biomarkers.&nbsp;<br> <strong>Methods</strong>: In this research, migraine genes are studies in terms of interaction pattern to introduce important individuals. Through STRING database Plug-in in Cytoscape, candidate genes for migraine were retrieved and analyzed by related applications. Based on centrality and action types (expression, activation, and inhibition) genes were screened.&nbsp;&nbsp;<br> <strong>Results</strong>: Numbers of 33 central genes including seven hub-bottlenecks were identified which 70% of central genes were involved in expression action with each other. Activation was dominate action relative to inhibition between the central genes.<br> <strong>Conclusion</strong>: The finding indicates that insulin is the most important gene relative to migraine. It seems regulation of metabolism play critical role in control of migraine.&nbsp;</div> Migraine disorders, Protein interaction maps, Genes 363 372 http://bcn.iums.ac.ir/browse.php?a_code=A-10-941-5&slc_lang=en&sid=1 Mona Zamanian-Azodi mona.azodi@gmail.com 13700319475328460021242 13700319475328460021242 Yes Student Research Committee, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Mostafa Rezaei-Tavirani tavirany@yahoo.com 13700319475328460021243 13700319475328460021243 No Proteomics Research Center, Faculty of Paramedical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Reza Mahmoud Robati mrobati@gmail.com 13700319475328460021244 13700319475328460021244 No Skin Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.