en Behavioral Neuroscience Behavioral Neuroscience Original Original <div style="text-align: justify;"><strong>Introduction: </strong>Donepezil (DON), an Acetylcholinesterase Inhibitor (AChEI), is widely used in the treatment of Alzheimer&rsquo;s Disease (AD). The current study aimed at evaluating the effect of donepezil hydrochloride on pyramidal neuron response in CA1 region of a rat model of AD.<br> <strong>Methods:</strong> In the current experimental study, adult male Wistar rats were randomly divided into four groups: Nucleus Basalis Magnocellularis (NBM) lesion (the lesions were induced by an electrical method of 0.5 m A, for 3 s in NBM) and three donepezil groups (lesions plus 5, 10, and 15 mg/kg donepezil intraperitoneal injection). Neuronal spontaneous activity to injection of the donepezil and saline were recorded in CA1 region of hippocampal.<br> <strong>Results:</strong> The obtained results showed that IntraPeritoneal (IP) injection of donepezil (10 and 15 mg/kg) increased neuronal spontaneous activity in the rat model of AD.<br> <strong>Conclusion: </strong>The current study results suggested that acute IP injection of donepezil increased neuronal response in CA1 region of hippocampal in a rat model of AD.&nbsp;</div> Alzheimer’s Disease, Electrophysiology, Donepezil, Rats 109 118 http://bcn.iums.ac.ir/browse.php?a_code=A-10-1360-1&slc_lang=en&sid=1 Azade Eskandary azade.eskandary@gmail.com 13700319475328460019489 13700319475328460019489 Yes Department of Biology, Faculty of Sciences, Shahid Chamran University of Ahvaz, Ahvaz, Iran. Ahmad Ali Moazedi a.moazedi@gmail.com 13700319475328460019490 13700319475328460019490 No Department of Biology, Faculty of Sciences, Shahid Chamran University of Ahvaz, Ahvaz, Iran. Hossein Najaph Zade najafzade@gmail.com 13700319475328460019491 13700319475328460019491 No Department of Basic Sciences, Faculty of Veterinary Medicine, Shahid Chamran University of Ahvaz, Ahvaz, Iran. Mohamad Reza Akhond m.akhond@gmail.com 13700319475328460019492 13700319475328460019492 No Department of Statistics, Faculty of Mathematical Sciences and Computer, Shahid Chamran University of Ahvaz, Ahvaz, Iran.