en Clinical Neuroscience Clinical Neuroscience Original Original <p style="margin: 0px 0px 16px; line-height: 150%;"><strong>Introduction</strong>: An impaired sense of smell has a remarkable impact on the quality of life. It is seen in a variety of neurodegenerative diseases such as Parkinson disease. In this study, we assessed the olfactory function in patients with Multiple Sclerosis (MS) by Sniff Magnitude Test (SMT).&nbsp;<br> <strong>Methods</strong>: A cross-sectional study was conducted on 48 patients with MS. A questionnaire, including demographic and clinical variables, was completed for each patient. The SMT was used for the evaluation of olfactory function.&nbsp;<br> <strong>Results</strong>: Olfactory dysfunction was found in 14.6% of patients (8.3% hyposmia and 6.3% anosmia). Older age, longer disease duration, higher hospital admission rate, lower mini-mental status examination score, and secondary progressive course of MS were significantly related to olfactory dysfunction.&nbsp;<br> <strong>Conclusion</strong>: Secondary progressive MS and markers of advanced disease toward neurodegenerative phase (including older age, longer disease duration, and lower cognitive function) can be associated with olfactory dysfunction in MS patients.</p> Smell, Olfaction disorders, Anosmia, Multiple Sclerosis, Secondary Progressive Multiple Sclerosis 89 94 http://bcn.iums.ac.ir/browse.php?a_code=A-10-1368-1&slc_lang=en&sid=1 Mostafa Almasi A_mostafa108@yahoo.com 13700319475328460031844 13700319475328460031844 No Department of Neurology, Firouzgar Hospital, Iran University of Medical Sciences, Tehran, Iran. Mohammad Ali Sahraian sahraian1350@yahoo.com 13700319475328460031845 13700319475328460031845 No Multiple Sclerosis Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran. Fahimeh Haji Akhoundi fhakhoundi@yahoo.com 13700319475328460031846 13700319475328460031846 No Department of Neurology, Firouzgar Hospital, Iran University of Medical Sciences, Tehran, Iran. Hamid Reza Ezzati hreezzati@gmail.com 13700319475328460031847 13700319475328460031847 No Department of Neurology, Hazrat Rasool Hospital, Iran University of Medical Sciences, Tehran, Iran. Mohammad Rohani mohammadroohani@gmail.com 13700319475328460031848 13700319475328460031848 Yes Department of Neurology, Hazrat Rasool Hospital, Iran University of Medical Sciences, Tehran, Iran.