Basic and Clinical Neuroscience Journal
مجله علوم اعصاب پایه و بالینی
BCN
Medical Sciences
http://bcn.iums.ac.ir
137
journal137
2008-126X
2228-7442
10.32598/bcn
en
jalali
1396
12
1
gregorian
2018
3
1
0
Accepted Articles
online
1
fulltext
en
Cerebrospinal Fluid Tau and Phosphotau As Biomarkers in Alzheimer's Disease Diagnosis
Cellular and molecular Neuroscience
Cellular and molecular Neuroscience
Review
Review
Dementia is a progressive disorder that leads to memory loss and cognition impairment and affects daily function. Alzheimer disease (AD) is the main cause of dementia that characterized by loss of memory and cognition. AD pathologically is demonstrated by neuronal atrophy, synapse loss and the unusual reposition of amyloid-β protein (Aβ) as senile plaques and hyperphosphorylated tau protein as neurofibrillary tangles (NFT). Tau is a microtubule associated protein mostly expressed in neurons. Site-specific phosphorylation regulates Tau function. In AD, the six adult tau isoforms are unusually phosphorylated that cause to form the paired helical filament. The different conditions of tau phosphorylation eventuate from the function of specific kinases and phosphatases. In recent years some biomarkers such as phospho tau 181, 199 and 231 had been assessed in cerebrospinal fluid (CSF) and blood and had been showed their elevation in AD. This article provides an overview of tau structure, functions, and its involvement in AD and its role as a CSF biomarker.<br>
Alzheimer, Tau, Phospho tau, Dementia,CSF biomarker, NFT
0
0
http://bcn.iums.ac.ir/browse.php?a_code=A-10-1136-3&slc_lang=en&sid=1
nahid
Ahmadian
ahmadiannahid@gmail.com
13700319475328460023481
13700319475328460023481
No
Tabriz University of Medical Sciences, Neurosciences Research Center (NSRC), Tabriz, Iran
Mahnaz
Talebi
Talebi511@yahoo.com
13700319475328460023482
13700319475328460023482
Yes
Tabriz University of Medical Sciences, Neurosciences Research Center (NSRC), Tabriz, Iran
Javad
Mahmoudi
mahmoudi2044@yahoo.com
13700319475328460023483
13700319475328460023483
No
Tabriz University of Medical Sciences, Neurosciences Research Center (NSRC), Tabriz, Iran
Saeed
sadig etegad
saeed.sadigetegad@gmail.com
13700319475328460023484
13700319475328460023484
No
Tabriz University of Medical Sciences, Neurosciences Research Center (NSRC), Tabriz, Iran
Alireza
Aghili
Talebi511@yahoo.com
13700319475328460023485
13700319475328460023485
No
Tabriz University of Medical Sciences, Neurosciences Research Center (NSRC), Tabriz, Iran