Basic and Clinical Neuroscience Journal
مجله علوم اعصاب پایه و بالینی
BCN
Medical Sciences
http://bcn.iums.ac.ir
137
journal137
2008-126X
2228-7442
10.32598/bcn
en
jalali
1397
12
1
gregorian
2019
3
1
10
2
online
1
fulltext
en
Curcumin-Loaded BSA Nanoparticles Protect More Efficiently Than Natural Curcumin Against Scopolamine-Induced Memory Retrieval Deficit
Behavioral Neuroscience
Behavioral Neuroscience
Original
Original
<div style="text-align: justify;"><strong>Introduction:</strong> There is evidence indicating that the rate of AD is lower in curry consuming populations. Then, there is an effort to elucidate if curcumin -as the main ingredient of turmeric- might affect the process of AD. However, in clinical trials of AD, a six-month curcumin treatment failed to show any progress, which might be attributable to its low bioavailability. In this line, a recent human study revealed that a more bioavailable solid lipid curcumin enhances cognition in aged adults. By the application of Bovine Serum Albumin (BSA), the current study aimed at converting curcumin to nano sizes and assessing its protective effects against scopolamine-induced passive avoidance memory retrieval deficit.<br>
<strong>Methods:</strong> Nanocurcumin was prepared via dissolution method. Male NMRI mice (20-25 g body weight) were used. The effective doses of nanocurcumin were selected according to the initial pilot test. The mice were treated with nanocurcumin 15 or 20 mg/kg/p.o or distilled water for 10 days. The animals were habituated and trained in passive avoidance apparatus on the day 10. The retention test was performed 24 hours later. Scopolamine (1 mg/kg/i.p.) or saline was injected 30 minutes before memory retention trial.<br>
<strong>Results:</strong> The findings indicated that nanocurcumin in doses 15 or 20 mg/kg/p.o prevented the retrieval deficit induced by scopolamine while natural curcumin in its equivalent doses did not have such an effect. Furthermore, nanocurcumin by itself improved memory retention comparing with the control group. <br>
<strong>Conclusion: </strong>These findings implied that the potential anti-amnesic effects of curcumin might be observed by producing and using its nanoformulation form.</div>
Curcumin, Albumin, Memory, Nanotechnology, Mice
157
164
http://bcn.iums.ac.ir/browse.php?a_code=A-10-1317-1&slc_lang=en&sid=1
Roksana
SoukhakLari
mmoosavi_2000@yahoo.com
13700319475328460019559
13700319475328460019559
No
Shiraz Neuroscience Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Leila
Moezi
moezil@sums.ac.ir
13700319475328460019560
13700319475328460019560
No
Nanobiology and Nanomedicine Research Centre, Shiraz University of Medical Sciences, Shiraz, Iran.
Fatema
Pirsalami
dibasalami@gmail.com
13700319475328460019561
13700319475328460019561
No
Department of Pharmacology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
Morteza
Abkar
mortezaabkar@gmail.com
13700319475328460019562
13700319475328460019562
No
Nanobiology and Nanomedicine Research Centre, Shiraz University of Medical Sciences, Shiraz, Iran.
Maryam
Moosavi
marmoosavi@sums.ac.ir
13700319475328460019563
13700319475328460019563
Yes
Shiraz Neuroscience Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.