Basic and Clinical Neuroscience Journal
مجله علوم اعصاب پایه و بالینی
BCN
Medical Sciences
http://bcn.iums.ac.ir
137
journal137
2008-126X
2228-7442
10.32598/bcn
en
jalali
1397
6
1
gregorian
2018
9
1
9
5
online
1
fulltext
en
Review Paper: Tau Pathology of Alzheimer Disease: Possible Role of Sleep Deprivation
Clinical Neuroscience
Clinical Neuroscience
Review
Review
<div style="text-align: justify;">Sleep deprivation is a common complaint in modern societies. Insufficient sleep has increased the risk of catching neurodegenerative diseases such as Alzheimer’s. Several studies have indicated that restricted sleep increases the level of deposition of β-amyloid and formation of neurofibrillary tangles, the major brain microstructural hallmarks for Alzheimer disease. The mechanisms by which sleep deprivation affects the pathology of Alzheimer disease has not yet been fully and definitively identified. However, risk factors like apolipoprotein E risk alleles, kinases and phosphatases dysregulation, reactive oxygen species, endoplasmic reticulum damages, glymphatic system dysfunctions and orexinergic system inefficacy have been identified as the most important factors which mediates between the two conditions. In this review, these factors are briefly discussed. <span dir="RTL"></span></div>
Neurofilament proteins, Tau proteins, Amyloid beta-peptides, Amyloid beta-protein precursor, Alzheimer's disease, Sleep disorder
307
316
http://bcn.iums.ac.ir/browse.php?a_code=A-10-1136-2&slc_lang=en&sid=1
Nahid
Ahmadian
ahmadiannahid@gmail.com
13700319475328460017559
13700319475328460017559
No
Neurosciences Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Sajjad
Hejazi
sajjadhejazi1@gmail.com
13700319475328460017560
13700319475328460017560
No
Department of Anatomy, Faculty of Veterinary Medicine, Tabriz Branch, Islamic Azad University, Tabriz, Iran
Javad
Mahmoudi
mahmoudi2044@yahoo.com
13700319475328460017561
13700319475328460017561
No
Neurosciences Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Mahnaz
Talebi
talebi511@yahoo.com
13700319475328460017562
13700319475328460017562
Yes
Neurosciences Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.