TY - JOUR JF - BCN JO - BCN VL - 13 IS - 6 PY - 2022 Y1 - 2022/11/01 TI - Repetitive Suicidal Behaviors in a Case With a New Mutation of Wolfram Syndrome: A Jump From the Gene to the Behavior TT - N2 - Wolfram syndrome (WS) is a rare autosomal recessive neurodegenerative disease with variable symptoms, including neuropsychiatric manifestations. A 26-year-old man was reported with classic symptoms of WS and repetitive psychiatric hospitalizations and at least 16 suicidal attempts. The genetic study demonstrated a novel homozygous stop-codon mutation on the WFS1 gene. This special type of mutation may be related to repetitive suicidal behaviors in this case of WS. Psychological support should be a routine practice in patients with WS. SP - 893 EP - 900 AU - Mirfazeli, Fatemeh Sadat AU - Mohebi, Fatemeh AU - Jahanbakhshi, Amin AU - Aryani, Omid AU - Almasi-Dooghaee, Mostafa AD - Department of Neurology, Firoozgar Hospital, Iran University of Medical Sciences, Tehran, Iran. KW - Wolfram syndrome KW - Suicidal behavior KW - Gene KW - Mutation KW - WFS1 gene UR - http://bcn.iums.ac.ir/article-1-2233-en.html DO - 10.32598/bcn.2021.910.3 ER -