RT - Journal Article T1 - Repetitive Suicidal Behaviors in a Case With a New Mutation of Wolfram Syndrome: A Jump From the Gene to the Behavior JF - BCN YR - 2022 JO - BCN VO - 13 IS - 6 UR - http://bcn.iums.ac.ir/article-1-2233-en.html SP - 893 EP - 900 K1 - Wolfram syndrome K1 - Suicidal behavior K1 - Gene K1 - Mutation K1 - WFS1 gene AB - Wolfram syndrome (WS) is a rare autosomal recessive neurodegenerative disease with variable symptoms, including neuropsychiatric manifestations. A 26-year-old man was reported with classic symptoms of WS and repetitive psychiatric hospitalizations and at least 16 suicidal attempts. The genetic study demonstrated a novel homozygous stop-codon mutation on the WFS1 gene. This special type of mutation may be related to repetitive suicidal behaviors in this case of WS. Psychological support should be a routine practice in patients with WS. LA eng UL http://bcn.iums.ac.ir/article-1-2233-en.html M3 10.32598/bcn.2021.910.3 ER -