%0 Journal Article %A Nasehi, Mohammad %T The Role of Hippocampal 5HT3 Receptors in Harmaline-Induced Memory Deficit %J Basic and Clinical Neuroscience Journal %V 6 %N 3 %U http://bcn.iums.ac.ir/article-1-560-en.html %R %D 2015 %K Memory reconsolidation, Glucocorticoids, Cholinergic agents, %X Introduction: The plethora of studies indicated that there is a cross talk relationship between harmaline and serotonergic (5-HT) system on cognitive and non-cognitive behaviors. Thus, the purpose of this study is to assess the effects of hippocampal 5-HT4 receptor on memory acquisition deficit induced by harmaline. Methods: Harmaline was injected peritoneally, while 5-HT4 receptor agonist (RS67333) and antagonist (RS23597-190) were injected intra-hippocampal. A single-trial step-down passive avoidance, open field and tail flick tasks were used for measurement of memory, locomotor activity and pain responses, respectively. Results: The data revealed that pre-training injection of higher dose of harmaline (1 mg/kg), RS67333 (0.5 ng/mouse) and RS23597-190 (0.5 ng/mouse) decreased memory acquisition process in the adult mice. Moreover, concurrent pre-training administration of subthreshold dose of RS67333 (0.005 ng/mouse) or RS23597-190 (0.005 ng/mouse) with subthreshold dose of harmaline (0.5 mg/kg, i.p.) intensify impairment of memory acquisition. All above interventions did not change locomotion and tail flick behaviors. Discussion: The results demonstrated that the synergistic effect between both hippocampal 5-HT4 receptor agonist and antagonist with impairment of memory acquisition induced by harmaline, indicating a modulatory effect for hippocampal 5HT4 receptor on Harmaline induced amnesia. %> http://bcn.iums.ac.ir/article-1-560-en.pdf %P 163-170 %& 163 %! %9 Original %L A-10-273-2 %+ Islamic Azad University, Garmsar Branch %G eng %@ 2008-126X %[ 2015