TY - JOUR T1 - Ischemic Postconditioning Attenuates Bilateral Renal Ischemia-induced Cognitive Impairments TT - JF - BCN JO - BCN VL - 12 IS - 6 UR - http://bcn.iums.ac.ir/article-1-1559-en.html Y1 - 2021 SP - 789 EP - 804 KW - Cognitive impairments KW - Acute kidney injury KW - Postconditioning KW - Brain-derived Neurotrophic Factor KW - Bilateral renal ischemia N2 - Introduction: Acute Kidney Injury (AKI) is a frequent complication of kidney failure with high mortality, leading to brain dysfunction. This study aimed to investigate the possible protective effect of Ischemic Postconditioning (IPo) against brain dysfunction induced by Bilateral Renal Ischemia (BRI). Methods: Male Wistar rats underwent BRI, sham, or IPo surgery 24h and 1w after reperfusion. The rats’ explorative behaviors and motor function were evaluated by an open field, rotarod, and wire grip tests. The cognitive function was assessed by passive avoidance learning and Morris water maze tests. Western blotting was performed to evaluate hippocampal Brain-Derived Neurotrophic Factor (BDNF) expression. Results: The impairment of balance function induced by BRI was not reversed; however, passive avoidance learning impairment was reversed by postconditioning 24h after reperfusion. IPo increased muscle strength compared to the BRI group; however, explorative behaviors and balance function had no difference 1w after reperfusion. BRI significantly decreased the BDNF protein expression in the hippocampus, and postconditioning increased 24h after reperfusion. Conclusion: The obtained results demonstrated the deleterious effect of BRI on cognitive and balance function 24h after reperfusion. IPo indicated a curative effect against cognitive dysfunction probably by enhancing BDNF protein expression in the hippocampus. M3 10.32598/bcn.2021.1941.1 ER -