TY - JOUR T1 - Evaluating the Antidepressant Effect of Verbena officinalis L. (Vervain) Aqueous Extract in Adult Rats TT - JF - BCN JO - BCN VL - 11 IS - 1 UR - http://bcn.iums.ac.ir/article-1-1480-en.html Y1 - 2020 SP - 91 EP - 98 KW - Aqueous extract KW - Depression KW - Neurobehavioral tests KW - Verbena officinalis L N2 - Introduction: The present study aimed to investigate the antidepressant effect of Verbena (V.) officinalis L. aqueous extract in adult female rats. Methods: The present study evaluated the antidepressant effect of V. officinalis L. aqueous (V AE) extract in female rats using the Forced-Swimming Test (FST), Light-Dark Box (LDB) test, and Open Field Test (OFT). The level of glycemia and histological analysis were also studied. The VAE [200 mg/kg Parenterally (PO)] was administered orally for 7 successive days in the separate groups of rats. Results: The oral administration of V. officinalis L. aqueous extract significantly decreased (P< 0.01) the immobility time in the FST, increased the time spent in the light area (LDB), and the number of entry into the central squares (OFT). Thus, the extract at a dose of 200 mg/kg significantly decreased the glycemia level (P<0.05) and suggested no harmful effect on brain histology. Conclusion: Verbena officinalis L. aqueous extract at a dose of 200 mg/kg could have an anti-depressant effect in adult rats. M3 10.32598/bcn.11.1.3 ER -