TY - JOUR T1 - MDMA and the Brain: A Short Review on the Role of Neurotransmitters in Neurotoxicit TT - JF - BCN JO - BCN VL - 11 IS - 4 UR - http://bcn.iums.ac.ir/article-1-1295-en.html Y1 - 2020 SP - 381 EP - 388 KW - MDMA KW - Neurotransmitter KW - Brain injuries KW - Memory KW - Therapy N2 - N-Methyl-3, 4-methylenedioxyamphetamine (MDMA), or ecstasy is a recreational drug of abuse. It is a synthetic substance that affects the body’s systems, which its mechanism of action and treatment should be more investigated. MDMA provides an immediate enjoyable feeling by stimulating the release of neurotransmitters, such as dopamine and serotonin in the brain. Unfortunately, abnormal regulation of the brain neurotransmitters, as well as the increased oxidative stress causes damage to the brain neurons after the MDMA exposure. Only a few studies have been done regarding its treatment. Thus, the treatment of MDMA complications should be further explored mainly by targeting its mechanism of action in the neurotransmitter systems. Hence, this study presents a short review regarding the recent findings on the role of neurotransmitters to cause MDMA neurotoxicity. The results will be useful for future research in elucidating the potential treatment based on the targeted mechanisms to treat the neurotoxic effects of MDMA. M3 10.32598/bcn.9.10.485 ER -