@ARTICLE{Soleimani Asl, author = {Soleimani Asl, Sara and Falahati, Peiman and shekar riz, Nima and Molavi, Nima and Esmaeili, Farzaneh and Azimi, Zahra and Sajadi, Freidoon and Hayat, Parisa and Samzadeh-Kermani, Alireza and Mehdizadeh, Mehdi and }, title = {Protective Effects of N-Acetyl-L-cystein on 3,4-Methylene Dioxymethamphetamie-Induced Neurotoxicity in Cerebellum of Male Rats}, volume = {3}, number = {1}, abstract ={Introduction: 3-4, methylenedioxymethamphetamine (MDMA) causes apoptosis in nervous system and several studies suggest that oxidative stress contributes to MDMA-induced neurotoxicity. The aim of this study is to examine the effects of N-acetyl-L-Cystein (NAC) as an antioxidant on MDMA-induced apoptosis. Methods: 21 Sprague dawley male rats (200-250mg) were treated with MDMA (2×0,5mg/kg) or MDMA plus NAC (100mg/kg IP for 7 day). After last administration of MDMA, rats were killed, cerebellum was removed and Bax and Bcl-2 expression was assessed by western blotting method. Results: The results of this study showed that MDMA causes up-regulation of Bax and down-regulation of Bcl-2 and NAC administration attenuated MDMA-induced apoptosis. Discussion: The present study suggests that NAC treatment may improve MDMA-induced neurotoxicity. }, URL = {http://bcn.iums.ac.ir/article-1-198-en.html}, eprint = {http://bcn.iums.ac.ir/article-1-198-en.pdf}, journal = {Basic and Clinical Neuroscience Journal}, doi = {}, year = {2011} }