RT - Journal Article T1 - The effect of oral administration of Withania somnifera root on formalin-induced pain in diabetic rats JF - BCN YR - 2009 JO - BCN VO - 1 IS - 1 UR - http://bcn.iums.ac.ir/article-1-12-en.html SP - 29 EP - 31 K1 - Withania somnifera K1 - Analgesia K1 - Diabetes mellitus K1 - Streptozotocin K1 - Rat AB -   Abstract  Introduction: Hyperalgesia is considered as one the marked signs of subchronic diabetes mellitus that could affect the life style of the patients. With c onsidering the potential anti-diabetic effect of the medicinal plant Withania somnifera (WS)( ashwagandha), this study was designed to investigate the analgesic effect of WS on formalin-induced nociceptive responses (standard formalin test) in diabetic rats. Methods: Rats were divided into control, WS-treated control, diabetic, sodium salicylate (SS)-treated control and diabetic and WS-treated diabetic groups. For induction of diabetes, streptozotocin (STZ) was used at a single dose. The treatment groups received oral administration of ashwagandha -mixed rat pellet (6.25%) for two months.  Results: The results showed that diabetic rats exhibited a higher score of pain at both phases of the formalin test and WS-treated diabetic rats exhibited a lower nociceptive score at both phases of the test (p LA eng UL http://bcn.iums.ac.ir/article-1-12-en.html M3 ER -