AU - Mehdizadeh, Mehdi AU - Katebi, Majid AU - Soleimani, Mansoure AU - Farahani Pad, Mohammad Hassan AU - Hoseini Tehrani, Ali AU - Taghi Joghataei, Mohammad TI - The Effect of Diazoxide on Ultrastructural Changes Following Ischemia-Reperfusion Injury of Rat Brain PT - JOURNAL ARTICLE TA - BCN JN - BCN VO - 1 VI - 3 IP - 3 4099 - http://bcn.iums.ac.ir/article-1-33-en.html 4100 - http://bcn.iums.ac.ir/article-1-33-en.pdf SO - BCN 3 AB  - A B S T R A C T Introduction: Even today there is no effective drug therapy to prevent neuronal loss after brain stroke. In the present study we studied the effect of mitochondrial KATP channel regulators on neuronal ultrastructure after ischemia reperfusion in the rat. Materials & Methods: Rats temporarily subjected to four vessels occlusion for 15 minutes followed by 24 hours reperfusion with or without K-ATP channel regulators. Results: Neuronal ultrastructure significantly improved in K-ATP channel opener (diazoxide) treated ischemia-reperfusion group compared with control group. Discussion: Our results showed that dizoxide treatment after ischemia reperfusion leads to better preservation of cortical neurons in rat. CP - IRAN IN - Mehdi Mehdizadeh, Ph.D of Anatomical Sciences, Fellowship of Transgenic Animals, Department of Anatomical Sciences, Cellular & Molecular Research Center, Iran University of Medical Sciences, Tehran, Iran, PO Box:15875-1454Tel/Fax:+98(21)88058689 maran LG - eng PB - BCN PG - 17 PT - Original YR - 2010