چکیده:
Purpose: Stroke is the second most common cause of death and the third leading factor for disability worldwide. Non-invasive brain stimulation (NIBS) has emerged as an effective option for enhancing cognitive function following stroke. This Network Meta-Analysis attempts to compare the effects of NIBS techniques, including rTMS and tCDS, on post-stroke cognitive function.
Methods: Interventional studies published between January 2018 to August 2024 were reviewed in Medline, Scopus, and Psycinfo databases. A total of 220 records were reviewed, and 12studies involving 510 participants met the inclusion criteria. The risk of bias was assessed using Cochrane collaboration tools.
The global cognition severity was quantified using the MMSE and MoCA scales, and the ADL abilities were evaluated using the MBI and FIM scales.
An NMA was performed using the Netmeta package in R to compare the efficacy of NIBS modalities and examine their impact across different recovery stages.
Results: NIBS significantly improved cognitive function compared with controls. Among modalities, rTMS showed the most substantial effects on global cognition (MoCA: p < 0.0001; MMSE: p = 0.001), with the greatest benefits observed in the subacute phase (p < 0.0001). No significant improvements were observed in ADLs, likely due to variability in measurement scales.
Conclusion:Both rTMS and tDCS significantly enhance post-stroke cognitive function, however rTMS demonstrates superior outcomes. The findings highlight the critical role of prompt intervention in optimizing rehabilitation potential.
Methods: Interventional studies published between January 2018 to August 2024 were reviewed in Medline, Scopus, and Psycinfo databases. A total of 220 records were reviewed, and 12studies involving 510 participants met the inclusion criteria. The risk of bias was assessed using Cochrane collaboration tools.
The global cognition severity was quantified using the MMSE and MoCA scales, and the ADL abilities were evaluated using the MBI and FIM scales.
An NMA was performed using the Netmeta package in R to compare the efficacy of NIBS modalities and examine their impact across different recovery stages.
Results: NIBS significantly improved cognitive function compared with controls. Among modalities, rTMS showed the most substantial effects on global cognition (MoCA: p < 0.0001; MMSE: p = 0.001), with the greatest benefits observed in the subacute phase (p < 0.0001). No significant improvements were observed in ADLs, likely due to variability in measurement scales.
Conclusion:Both rTMS and tDCS significantly enhance post-stroke cognitive function, however rTMS demonstrates superior outcomes. The findings highlight the critical role of prompt intervention in optimizing rehabilitation potential.
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