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1- Mental Health Research Center, Psychosocial Health Research Institute, Iran University of Medical Sciences, Tehran, Iran.
2- School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
3- Skull Base Research Center, Neurosurgery Department, Rasool Akram Hospital, Iran University of Medical Sciences, Tehran, Iran.
4- Endocrinology and Metabolism Research Institute, Tehran University of Medical Sciences, Tehran, Iran.
5- Neurology Department, Firoozgar Hospital, Iran University of Medical Sciences, Tehran, Iran.
Abstract:  
Wolfram syndrome (WS) is a rare autosomal recessive neurodegenerative disease with variable symptoms including neuropsychiatric manifestations. A 26-year-old man was reported with classic symptoms of WS and repetitive psychiatric hospitalizations and at least 16 suicidal attempts. The genetic study demonstrated a novel homozygous stop-codon mutation on the WFS1 gene. This special type of mutation may be related to repetitive suicidal behaviors in this case of WS. Psychological support should be a routine practice in patients with WS.
Type of Study: Original | Subject: Clinical Neuroscience
Received: 2021/07/18 | Accepted: 2021/08/23

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