● COVID-19 has changed the world and the educational and clinical activities.
● Virtual learning was increasingly substitute in-person learning during COVID outbreak.
● Telemedicine is a suitable approach in providing effective and safe healthcare.
● Any strategy of educational and clinical activities should be flexible during crisis.

Plain Language Summary 
The new Coronavirus Virus 2019 (COVID-19) has changed the world recently. The medical education and clinical practice were affected, as well. The contributing factors were providing social isolation to reduce the virus spreading, limitation in protective equipment, and transferring available sources to facing COVID-19. Therefore, having flexible strategies may help us to manage the critical situation. Neurology Department of Firoozgar hospital, affiliated to Iran University of Medical Science (IUMS), has made some changes in routine clinical and educational activities since the emergence of outbreak. Although the number of active staff and residents were reduced significantly, the in-person educational and clinical activities were converted to virtual learning and tele-medicine, respectively. The virtual space helped up to join with our colleagues in other centers and share our educational activities. The number of educational classes was increased fifteenth times at the second month of the outbreak, compared to the first month. Even more, this amount was doubled in respect to one month before outbreak. Tele-medicine including online follow-up of patients using telephone or internet was applied, especially for those patients underwent immunosuppressive medications. A multidisciplinary online team helped us for quick management of patients and reduce the time of hospitalization.Finally, changing the strategy from in-person practice to virtual learning and tele-medicine is a practical and useful model which is recommended for other centers at the pandemic crisis.