● This study evaluated the opinion of patients with MS on the outcomes of COVID-19 and its effects on MS symptoms.
● The most important concern of the participants was “a high prevalence of COVID-19” following by the “MS symptoms worsening”.
● This study revealed that MS patients are anxious about the effects of COVID-19 on their underlying disease.
Plain Language Summary 
Due to the ongoing pandemic of COVID-19 and the increased risk of infection in MS patients, we conducted a cross-sectional study to assess the major concerns of MS patients in this regard. A total of 148 MS patients with a mean age of 35.73 years were enrolled in this study and completed the designed form. Although death was thought to be the main concern of COVID-19 patients, our study showed that the high prevalence of the disease and the worsening of MS disease due to COVID-19 infection were the major concerns of MS patients. According to the answers to the third question, more than 60% of patients believed that COVID-19 could induce MS attack or worsen their disease process.Relapsing-remitting MS patients typically experience the stable state of their disease and were more worried about the high prevalence of COVID-19, while the most concern of primary progressive MS participants was the worsening of MS disease due to COVID-19 infection, maybe due to progressive nature of their underlying disease. They were mostly concerned about the impact of COVID-19 on MS rather than the disease itself.