دوره 9، شماره 5 - ( September & October 2018 1397 )                   جلد 9 شماره 5 صفحات 346-337 | برگشت به فهرست نسخه ها


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Zamanian-Azodi M, Rezaei-Tavirani M, Mahboubi M, Hamidpour M, Rezaei Tavirani M, Hamdieh M, et al . Serum Proteomic Study of Women With Obsessive-Compulsive Disorder, Washing Subtype. BCN 2018; 9 (5) :337-346
URL: http://bcn.iums.ac.ir/article-1-1091-fa.html
Serum Proteomic Study of Women With Obsessive-Compulsive Disorder, Washing Subtype. مجله علوم اعصاب پایه و بالینی. 1397; 9 (5) :337-346

URL: http://bcn.iums.ac.ir/article-1-1091-fa.html


چکیده:  
Introduction: Many genetic studies are conducted on Obsessive-Compulsive Disorder (OCD). however, a high-throughput examination of proteome profile of this severe disease has not been performed yet. 
Methods: Here, the proteomic study of OCD patients’ serum samples was conducted by the application of Two-Dimensional Electrophoresis (2DE) followed by Mass Spectrometry (MALDI-TOF-TOF). 
Results: A total of 240 protein spots were detected and among them, five significant differentially expressed protein spots with the fold change of ≥1.5 were considered for further evaluations. These proteins include IGKC, GC, HPX, and two isoforms of HP. While IGKC and HP show down-regulation, GC and HPX indicate up-regulation. Moreover, a validation study of overall HP levels in patients’ serum via nephelometric quantification confirmed the lower levels of this protein in the serum of OCD patients. Additionally, enrichment analysis and validation test revealed that inflammation is one of most dominant processes in OCD. 
Conclusion: It is suggested that these candidate proteins and their underlying processes (especially, inflammation) may be linked to OCD pathophysiology and can promise a clinical use after extensive validation studies.
نوع مطالعه: Original | موضوع مقاله: Behavioral Neuroscience
دریافت: 1396/9/15 | پذیرش: 1396/12/5 | انتشار: 1397/6/10

فهرست منابع
1. Assenov, Y., Ramírez, F., Schelhorn, S.E., Lengauer, T., & Albrecht, M. (2007). Computing topological parameters of biological networks. Bioinformatics, 24(2), 282-4. [DOI:10.1093/bioinformatics/btm554] [PMID] [DOI:10.1093/bioinformatics/btm554]
2. Attwells, S., Setiawan, E., Wilson, A.A., Rusjan, P.M., Mizrahi, R., Miler, L., et al. (2017). Inflammation in the neurocircuitry of obsessive-compulsive disorder. JAMA Psychiatry, 74(8), 833-40. [DOI:10.1001/jamapsychiatry.2017.1567] [DOI:10.1001/jamapsychiatry.2017.1567]
3. Behl, A., Swami, G., Sircar, S., Bhatia, M., & Banerjee, B. (2010). Relationship of possible stress-related biochemical markers to oxidative/antioxidative status in obsessive-compulsive disorder. Neuropsychobiology, 61(4), 210-4. [DOI:10.1159/000306591] [DOI:10.1159/000306591]
4. Celik, G., Tas, D. A., Varmıs, D. A., Tahiroglu, A., & Avci, A. (2016). Vitamin D insufficiency in a boy with obsessive–compulsive disorder. Pediatrics International, 58(7), 646-8. [DOI:10.1111/ped.12941] [PMID] [DOI:10.1111/ped.12941]
5. Dickerson, F., Stallings, C., Origoni, A., Vaughan, C., Khushalani, S., Yang, S., et al. (2013). C-reactive protein is elevated in schizophrenia. Schizophrenia Research, 143(1), 198-202. [DOI:10.1016/j.schres.2012.10.041] [DOI:10.1016/j.schres.2012.10.041]
6. Esnafoğlu, E., & Yaman, E. (2017). Vitamin B12, folic acid, homocysteine and vitamin D levels in children and adolescents with obsessive compulsive disorder. Psychiatry Research, 254, 232-7. [DOI:10.1016/j.psychres.2017.04.032] [DOI:10.1016/j.psychres.2017.04.032]
7. Fan, S., van den Heuvel, O. A., Cath, D. C., van der Werf, Y. D., De Wit, S. J., de Vries, F. E., et al. (2015). Mild white matter changes in un-medicated obsessive-compulsive disorder patients and their unaffected siblings. Frontiers in Neuroscience, 9, 495. [DOI:10.3389/fnins.2015.00495] [DOI:10.3389/fnins.2015.00495]
8. Föcking, M., Dicker, P., Lopez, L. M., Hryniewiecka, M., Wynne, K., English, J. A., et al. (2016). Proteomic analysis of the postsynaptic density implicates synaptic function and energy pathways in bipolar disorder. Translational Psychiatry, 6(11), e959. [DOI:10.1038/tp.2016.224] [DOI:10.1038/tp.2016.224]
9. Frye, M. A., Nassan, M., Jenkins, G., Kung, S., Veldic, M., Palmer, B., et al. (2015). Feasibility of investigating differential proteomic expression in depression: implications for biomarker development in mood disorders. Translational Psychiatry, 5(12), e689. [DOI:10.1038/tp.2015.185] [DOI:10.1038/tp.2015.185]
10. Hasanzadeh, H., Rezaie-Tavirani, M., Seyyedi, S., Emadi, A. (2015). [Proteomics Study of extremely low frequency electromagnetic field (50 Hz) on human neuroblastoma cells (Persian)]. Koomesh, 17(1), 233-8.
11. Jaffe, A., Deep Soboslay, A., Tao, R., Hauptman, D., Kaye, W., Arango, V., et al. (2014). Genetic neuropathology of obsessive psychiatric syndromes. Translational Psychiatry, 4(9), e432. [DOI:10.1038/tp.2014.68] [DOI:10.1038/tp.2014.68]
12. Karbalaei, R., Piran, M., Rezaei Tavirani, M., Asadzadeh Aghdaei, H., & Heidari, M. H. (2017). One systems biology analysis protein-protein interaction of NASH and IBD based on comprehensive gene information. Gastroenterology and Hepatology from Bed to Bench, 10(3), 194-201. [PMID] [PMCID] [PMID] [PMCID]
13. Korth, C., Bader, V., Trossbach, S., Hamburg, H., Marreiros, R., Ottis, P., et al. (2017). Functional proteomics backed by genetics and reverse genetic engineering: A novel successful approach to identify schizophrenia subsets. European Neuropsychopharmacology, 27(3), S510. [DOI:10.1016/j.euroneuro.2016.09.619] [DOI:10.1016/j.euroneuro.2016.09.619]
14. Lohr, M., Edlund, K., Botling, J., Hammad, S., Hellwig, B., Othman, A., et al. (2013). The prognostic relevance of tumour-infiltrating plasma cells and immunoglobulin kappa C indicates an important role of the humoral immune response in non-small cell lung cancer. Cancer Letters, 333(2), 222-8. [DOI:10.1016/j.canlet.2013.01.036] [DOI:10.1016/j.canlet.2013.01.036]
15. Zamanian Azodi, M., Rezaei Tavirani, M., Arefi Oskouie, A., Hamdieh, M., Derakhshan, M. K., Ahmadzadeh, A., et al. (2017). Fluoxetine regulates Ig kappa chain c region expression levels in the serum of obsessive-compulsive disorder patients: A proteomic approach. Iranian Journal of Pharmaceutical Research, 16(3), 1264-71. [PMCID] [PMID] [PMCID]
16. Maes, M., Delange, J., Ranjan, R., Meltzer, H. Y., Desnyder, R., Cooremans, W., et al. (1997). Acute phase proteins in schizophrenia, mania and major depression: Modulation by psychotropic drugs. Psychiatry Research, 66(1),1-11. [DOI:10.1016/S0165-1781(96)02915-0] [DOI:10.1016/S0165-1781(96)02915-0]
17. Mattheisen, M., Samuels, J. F., Wang, Y., Greenberg, B. D., Fyer, A. J., McCracken, J. T., et al. (2015). Genome-wide association study in obsessive-compulsive disorder: Results from the OCGAS. Molecular Psychiatry, 20(3), 337-44. [DOI:10.1038/mp.2014.43] [DOI:10.1038/mp.2014.43]
18. Mendez-David, I., Boursier, C., Domergue, V., Colle, R., Falissard, B., Corruble, E., et al. (2017). Differential peripheral proteomic biosignature of fluoxetine response in a mouse model of anxiety/depression. Frontiers in Cellular Neuroscience, 11, 237. [DOI:10.3389/fncel.2017.00237] [DOI:10.3389/fncel.2017.00237]
19. Petrov, B.R. (2017). A new role for vitamin D binding protein in bipolar disorder [MSc. thesis]. Columbus, Ohio: The Ohio State University.
20. Rasmussen, L. J. H., Schultz, M., Gaardsting, A., Ladelund, S., Garred, P., Iversen, K., et al. (2017). Inflammatory biomarkers and cancer: CRP and suPAR as markers of incident cancer in patients with serious nonspecific symptoms and signs of cancer. Radiation Oncology Investigations, 141(1), 191-9. [DOI:10.1002/ijc.30732] [DOI:10.1002/ijc.30732]
21. Safaei, A., Tavirani, M. R., Azodi, M. Z, Lashay, A., Mohammadi, S. F., Broumand, M. G., et al. (2017). Diabetic retinopathy and laser therapy in rats: A protein-protein interaction network analysis. Journal of Lasers in Medical Sciences, 8(3), 20-1. [DOI:10.15171/jlms.2017.s4] [DOI:10.15171/jlms.2017.s4]
22. Sarokhani, D., Sarokhani, M., Sayehmiri, K., & Azodi, M. Z. (2016). The evaluation of obsessive-compulsive disorder prevalence in iran: a meta-analysis and systematic review. International Journal of Pharmacy & Technology, 8(4), 21482-92.
23. Seal, U. S., Eist, H. (1996). Elevation of serum protein-bound carbohydrates and haptoglobin in schizophrenia. Clinical Chemistry, 12(10), 709-16.
24. Shannon, P., Markiel, A., Ozier, O., Baliga, N. S., Wang, J. T., Ramage, D., et al. (2003). Cytoscape: A software environment for integrated models of biomolecular interaction networks. Genome Research, 13(11), 2498-504. [DOI:10.1101/gr.1239303] [PMID] [PMCID] [DOI:10.1101/gr.1239303]
25. Sherman, B. T., & Lempicki, R. A. (2009). Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources. Nature Protocols, 4(1), 44-57. [DOI:10.1038/nprot.2008.211] [DOI:10.1038/nprot.2008.211]
26. Shrivastava, A., Kar, S. K., Sharma, E., Mahdi, A. A., & Dalal, P. K. (2017). A study of oxidative stress biomarkers in obsessive compulsive disorder. Journal of Obsessive-Compulsive and Related Disorders, 15, 52-6.[DOI:10.1016/j.jocrd.2017.09.004] [DOI:10.1016/j.jocrd.2017.09.004]
27. Sinopoli, V., Burton, C. L., Kronenberg, S., & Arnold, P. D. (2017). A review of the role of serotonin system genes in obsessive-compulsive disorder. Neuroscience & Biobehavioral Reviews, 80, 372-81. [DOI:10.1016/j.neubiorev.2017.05.029] [PMID] [DOI:10.1016/j.neubiorev.2017.05.029]
28. Szklarczyk, D., Morris, J. H., Cook, H., Kuhn, M., Wyder, S., Simonovic, M., et al. (2017). The STRING database in 2017: Quality-controlled protein–protein association networks, made broadly accessible. Nucleic Acids Research, 45(D1), D362-D8. [DOI:10.1093/nar/gkw937] [DOI:10.1093/nar/gkw937]
29. Tang, H. Y., Beer, L. A., & Speicher, D. W. (2011). In-depth analysis of a plasma or serum proteome using a 4D protein profiling method. Methods in Molecular Biology, 728, 47-67. [DOI:10.1007/978-1-61779-068-3_3] [PMID] [PMCID] [DOI:10.1007/978-1-61779-068-3_3]
30. Taylor, S. (2013). Molecular genetics of obsessive–compulsive disorder: A comprehensive meta-analysis of genetic association studies. Molecular Psychiatry, 18(7), 799-805. [DOI:10.1038/mp.2012.76] [DOI:10.1038/mp.2012.76]
31. Tolosano, E., & Altruda, F. (2002). Hemopexin: Structure, function, and regulation. DNA and Cell Biology, 21(4), 297-306. [DOI:10.1089/104454902753759717] [PMID] [DOI:10.1089/104454902753759717]
32. Tseng, C. F., Lin, C. C., Huang, H. Y., Liu, H. C., & Mao, S. J. (2004). Antioxidant role of human haptoglobin. Proteomics, 4(8), 2221-8. [DOI:10.1002/pmic.200300787] [PMID] [DOI:10.1002/pmic.200300787]
33. Zamanian Azodi, M., Rezaei Tavirani, M., Kermani Ranjbar, T., Arefi Oskouie, A., Rezaei Tavirani, M., Rahmati Rad, S., et al. (2015). [Pathophysiology, genetics, types, and treatments in obsessive compulsive disorder (Persian)]. Koomesh, 16(4), 475-87.
34. Zamanian Azodi, M., Rezaei Tavirani, M., Nejadi, N., Arefi Oskouie, A., Zayeri, F., Hamdieh, M., et al. (2017). Serum proteomic profiling of obsessive-compulsive disorder, washing subtype: A preliminary study. Basic and Clinical Neuroscience, 8(4), 307-16. [DOI:10.18869/nirp.bcn.8.4.307] [DOI:10.18869/nirp.bcn.8.4.307]

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