Volume 6, Issue 3 (Summer 2015 -- 2015)                   BCN 2015, 6(3): 163-170 | Back to browse issues page

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Nasehi M. The Role of Hippocampal 5HT3 Receptors in Harmaline-Induced Memory Deficit. BCN. 2015; 6 (3) :163-170
URL: http://bcn.iums.ac.ir/article-1-560-en.html
Islamic Azad University, Garmsar Branch

Introduction: The plethora of studies indicated that there is a cross talk relationship between harmaline and serotonergic (5-HT) system on cognitive and non-cognitive behaviors. Thus, the purpose of this study is to assess the effects of hippocampal 5-HT4 receptor on memory acquisition deficit induced by harmaline. 

Methods: Harmaline was injected peritoneally, while 5-HT4 receptor agonist (RS67333) and antagonist (RS23597-190) were injected intra-hippocampal. A single-trial step-down passive avoidance, open field and tail flick tasks were used for measurement of memory, locomotor activity and pain responses, respectively. 
Results: The data revealed that pre-training injection of higher dose of harmaline (1 mg/kg), RS67333 (0.5 ng/mouse) and RS23597-190 (0.5 ng/mouse) decreased memory acquisition process in the adult mice. Moreover, concurrent pre-training administration of subthreshold dose of RS67333 (0.005 ng/mouse) or RS23597-190 (0.005 ng/mouse) with subthreshold dose of harmaline (0.5 mg/kg, i.p.) intensify impairment of memory acquisition. All above interventions did not change locomotion and tail flick behaviors. 
Discussion: The results demonstrated that the synergistic effect between both hippocampal 5-HT4 receptor agonist and antagonist with impairment of memory acquisition induced by harmaline, indicating a modulatory effect for hippocampal 5HT4 receptor on Harmaline induced amnesia.
Type of Study: Original | Subject: Behavioral Neuroscience
Received: 2014/11/30 | Accepted: 2015/04/25 | Published: 2015/07/1

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