Volume 5, Issue 2 (Spring 2014 2014)                   BCN 2014, 5(2): 162-168 | Back to browse issues page

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Sofiabadi M, Azhdari Zarmehri H, Naderi F, Ghalandri M, Sonboli A, Haghprast A. Effects of Hydroalcoholic Extract of Tanacetum Sonbolii (Asteraceae) on Pain-related Behaviors during Formalin Test in Mice. BCN. 2014; 5 (2) :162-168
URL: http://bcn.iums.ac.ir/article-1-379-en.html
1- Cellular and Molecular Research Center, Qazvin University of Medical Sciences, Qazvin, Iran.
2- Department of Basic Sciences, Torbat Heydariyeh University of Medical Sciences, Torbat Heydariyeh, Iran.
3- Physiology–Pharmacology Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.
4- Department of Biology, Medicinal Plants and Drugs Research Institute, Shahid Beheshti University, G.C., Evin, Tehran, Iran.
5- Neuroscience Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Introduction: Tanacetum sonbolii (Asteraceae) is an endemic species in Iran. In the present study, we examined the effects of Tanacetum sonbolii hydroalcoholic extract on the formalin test in mice. Methods: 126 Swiss albino mice weighing 230-280g were used as subjects. The formalin test was performed on two control groups (marked as intact and saline groups n = 6 in each group) and an experimental group. In all groups, the formalin test was recorded for 60 min after administration of extract and drugs in mice. Results: The results showed that Tanacetum sonbolii (150 and 300 mg/kg) produced significant antinociception in phase 2. In addition, different doses of Tanacetum sonbolii extract (600, 900 and 1200 mg/kg) also induced antinociceptive effects in phase1 and phase 2. On the other hand, morphine could induce antinociception in a dose-dependent manner. Diclofenac (10 mg/kg) failed to affect the pain scores compared to Tanacetum sonbolii (300 mg/kg) group. Discussion: It seems that administration of hydroalcoholic extract of Tanacetum sonbolii has the potential to relieve pain through both central and peripheral mechanisms in persistent inflammatory nociception.

Type of Study: Original | Subject: Behavioral Neuroscience
Received: 2013/09/20 | Accepted: 2014/01/10 | Published: 2014/04/1

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