en Cellular and molecular Neuroscience Cellular and molecular Neuroscience Review Review <div style="text-align: justify;"><span style="font-size:14px;"><span style="font-family:Tahoma;"><span style="line-height:2;"><span lang="EN-IN">Epilepsy is a chronic neurological disease caused by anomalous neuronal action that displays as persistent, irrational, frequent seizures with frothing at the mouth, leading to a significant global health burden. Valproic acid (VPA) is a widely prescribed antiepileptic drug (AED) that has demonstrated efficacy in treating various types of seizures. Besides its anticonvulsant properties, emerging evidence proposes that VPA employs neuroprotective efficacy, possibly improving the progression of epilepsy and mitigating its related neurological damage. It represents a drug of choice in children and adults with epilepsy, with either general or focal seizures. This review highlights the signalling pathways modulated by VPA with a translational purpose, preclinical and clinical studies investigating the neuroprotective mechanisms supporting VPA&#39;s neuroprotective role in epilepsy, and identifies the areas for future research.</span></span></span></span></div> Valproic acid, epilepsy, neuroprotection, mechanisms of action, preclinical studies, clinical studies 0 0 http://bcn.iums.ac.ir/browse.php?a_code=A-10-8502-1&slc_lang=en&sid=1 Sana Nafees sanabiosciences@gmail.com 13700319475328460058420 13700319475328460058420 Yes Dept. Biomedical Sciences College of Clinical Pharmacy King Faisal University, Al Ahsa 31982, Saudi Arabia Abdulaziz Khalid Al Mouslem aalmoslem@kfu.edu.sa 13700319475328460058421 13700319475328460058421 No Department of Pharmaceutical Sciences, College of Clinical Pharmacy, King Faisal University, Al Ahsa 31982, Saudi Arabia Bushra Zeya bushrazeya@gmail.com 13700319475328460058422 13700319475328460058422 No Department of Biosciences, Jamia Millia Islamia, New Delhi-110025, India Abul Vafa alwafakhan@gmail.com 13700319475328460058423 13700319475328460058423 No Department of Biotechnology, Jamia Hamdard, New Delhi-110062, India