en Cognitive Neuroscience Cognitive Neuroscience Original Original <div style="text-align: justify;"><span style="font-size:14px;"><span style="font-family:Tahoma;"><span style="line-height:2;"><span style="background:white"><b><span style="color:#222222">Objectives</span></b><span style="color:#222222">: This study aimed to investigate the effects of transcranial direct current stimulation (tDCs) on resting-state electroencephalography (EEG) mean frequency and motor recovery in patients with chronic stroke.</span></span><br> <span style="background:white"><b><span style="color:#222222">Methods: </span></b><span style="color:#222222">Thirty individuals with chronic stroke were randomly allocated to receive either real or sham anodal tDCs combined with task-oriented training (TOT). The real-tDCs group received 2 mA anodal stimulation over the motor cortex for 20 minutes per session, five times per week, for three weeks. EEG mean frequency and the Fugl-Meyer Assessment (FMA) of the upper extremity were used as the main and secondary outcomes, respectively.</span></span><br> <span style="background:white"><b><span style="color:#222222">Results</span></b><span style="color:#222222">: Both groups demonstrated a gradual reduction in EEG mean frequency over time, with a more pronounced decrease in the sham group. This difference was statistically significant only at follow-up (<i>P = 0.02</i>). The FMA scores improved significantly in both groups (<i>P < 0.001</i>), with a greater improvement trend in the real-tDCs group; however, intergroup differences were not significant.</span></span><br> <span style="background:white"><b><span style="color:#222222">Conclusion: </span></b><span style="color:#222222">Although the association between EEG mean frequency and motor performance remains inconclusive, these findings suggest that anodal tDCs may modulate cortical activity and support motor recovery in chronic stroke patients.</span></span></span></span></span></div> transcranial direct current stimulation, task-oriented training, EEG mean frequency, motor recovery, stroke, neurorehabilitation 0 0 http://bcn.iums.ac.ir/browse.php?a_code=A-10-8437-1&slc_lang=en&sid=1 Maryam Zolghadr mzolghadr.pt128@gmail.com 13700319475328460059116 13700319475328460059116 No Rehabilitation Research Center, Department of Physical Therapy, School of Rehabilitation, Iran University of Medical Sciences, Tehran, Iran Javad Sarrafzadeh sarrafzadehjavadpt@gmail.com 13700319475328460059117 13700319475328460059117 Yes Rehabilitation Research Center, Department of Physical Therapy, School of Rehabilitation, Iran University of Medical Sciences, Tehran, Iran Shohreh Noorizadeh Dehkordi shohrehnoorizadehdehkordi@gmail.com 13700319475328460059118 13700319475328460059118 No Rehabilitation Research Center, Department of Physical Therapy, School of Rehabilitation, Iran University of Medical Sciences, Tehran, Iran Saeed Talebian stalebianpt@gmail.com 13700319475328460059119 13700319475328460059119 No Department of Physical Therapy, School of Rehabilitation, Tehran University of Medical Sciences, Tehran, Iran Marzieh Yassin m.yassin.pt@gmail.com 13700319475328460059120 13700319475328460059120 No Rehabilitation Research Center, Department of Physical Therapy, School of Rehabilitation, Iran University of Medical Sciences, Tehran, Iran Hassan Haddadzade Niri haddadzadeniri.h@iums.ac.ir 13700319475328460059121 13700319475328460059121 No Rehabilitation Research Center, Department of Physical Therapy, School of Rehabilitation, Iran University of Medical Sciences, Tehran, Iran